Tau represents the subunit protein of one of the major hallmarks of Alzheimer disease (AD),
the neurofibrillary tangles, and is therefore of major interest as an indicator of disease …

The last 15 years have seen a paradigm shift in our understanding of protein biochemistry,
with the realization that an unexpectedly high fraction of the human genome codes for …

Various physics-and data-driven sequence-dependent protein coarse-grained models have
been developed to study biomolecular phase separation and elucidate the dominant …

Many intrinsically disordered proteins (IDPs) may undergo liquid–liquid phase separation
(LLPS) and participate in the formation of membraneless organelles in the cell, thereby …

The formation and viscoelastic properties of condensates of intrinsically disordered proteins
(IDPs) is dictated by amino acid sequence and solution conditions. Because of the …

Coarse-grained molecular dynamics simulations are a useful tool to determine
conformational ensembles of proteins. Here, we show that the coarse-grained force field …

Multidomain proteins with flexible linkers and disordered regions play important roles in
many cellular processes, but characterizing their conformational ensembles is difficult. We …

Alzheimer disease is characterized by abnormal protein deposits in the brain, such as
extracellular amyloid plaques and intracellular neurofibrillary tangles. The tangles are made …

Protein folding in the cell relies on the orchestrated action of conserved families of molecular
chaperones, the Hsp70 and Hsp90 systems. Hsp70 acts early and Hsp90 late in the folding …

While the crucial role of intrinsically disordered proteins (IDPs) in the cell cycle is now
recognized, deciphering their molecular mode of action at the structural level still remains …