Myocardial necrosis triggers an inflammatory reaction that clears the wound from dead cells
and matrix debris, while activating reparative pathways necessary for scar formation. A …

Myocardial infarction is defined as sudden ischemic death of myocardial tissue. In the
clinical context, myocardial infarction is usually due to thrombotic occlusion of a coronary …

Active resolution of acute inflammation is a previously unrecognized interface between
innate and adaptive immunity. Once thought to be a passive process, the resolution of …

Acute inflammation normally resolves by mechanisms that have remained somewhat
elusive. Emerging evidence now suggests that an active, coordinated program of resolution …

Ischemia-reperfusion injury is a common feature of ischemic stroke, which occurs when
blood supply is restored after a period of ischemia. Reperfusion can be achieved either by …

Endogenous mechanisms that orchestrate resolution of acute inflammation are essential in
host defense and the return to homeostasis. Resolvin (Rv) D2 is a potent immunoresolvent …

Abstract Leukotrienes (LTs) and prostaglandins (PGs) amplify acute inflammation, whereas
lipoxins (LXs) have unique anti-inflammatory actions. Temporal analyses of these …

Aspirin therapy inhibits prostaglandin biosynthesis without directly acting on lipoxygenases,
yet via acetylation of cyclooxygenase 2 (COX-2) it leads to bioactive lipoxins (LXs) epimeric …

Resolution of inflammation and the return of tissues to homeostasis are essential. Efforts to
identify molecular events governing termination of self-limited inflammation uncovered …

It is with great pleasure that I write this foreword and introduction to this Special Issue
dedicated to the protective actions of the pro-resolving mediators and edited by my …