The rise of antimicrobial resistance has positioned ESKAPE pathogens as a serious global
health threat, primarily due to the limitations and frequent failures of current treatment …

Non-alcoholic fatty acid liver disease (NAFLD), non-alcoholic steatohepatitis (NASH) and
hepatocellular carcinoma (HCC) are the fatal liver diseases which encompass a spectrum of …

RNA polymerase is an essential enzyme involved in bacterial transcription, playing a crucial
role in RNA synthesis. However, it requires the association with sigma factors to initiate this …

Bacterial RNA polymerase (RNAP), the core enzyme responsible for bacterial transcription,
requires the NusG factor for efficient transcription elongation and termination. As the primary …

The rapid rise of antibiotic-resistant bacterial strains is a significant global health issue,
necessitating the development of new and effective antimicrobial agents. This study focuses …

Antifungal peptides (AFPs) are emerging as promising candidates for advanced antifungal
therapies because of their broad-spectrum efficacy and reduced resistance development. In …

This study aimed to design and synthesise novel guaiacol–chalcone and nitroguaiacol–
chalcone derivatives and determine their in vitro antibacterial activity against five pathogens …

Introduction Staphylococcus aureus is a highly resistant pathogen. It has multiple virulence
factors, which makes it one of the most pathogenic bacteria for humankind. The vast …

The increasing prevalence of multidrug-resistant pathogens necessitates the urgent
development of new antimicrobial agents with innovative modes of action for the next …

Medicinal plants are enriched sources of drugs due to their chemically and functionally
diverse secondary metabolites. Conventional methods of screening these bioactive …