Small molecule metabolites: discovery of biomarkers and therapeutic targets
S Qiu, Y Cai, H Yao, C Lin, Y **e, S Tang… - Signal Transduction and …, 2023 - nature.com
Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …
Fighting antibiotic resistance—strategies and (pre) clinical developments to find new antibacterials
Antibacterial resistance is one of the greatest threats to human health. The development of
new therapeutics against bacterial pathogens has slowed drastically since the approvals of …
new therapeutics against bacterial pathogens has slowed drastically since the approvals of …
Microbial metabolites in the marine carbon cycle
One-quarter of photosynthesis-derived carbon on Earth rapidly cycles through a set of short-
lived seawater metabolites that are generated from the activities of marine phytoplankton …
lived seawater metabolites that are generated from the activities of marine phytoplankton …
Mining genomes to illuminate the specialized chemistry of life
All organisms produce specialized organic molecules, ranging from small volatile chemicals
to large gene-encoded peptides, that have evolved to provide them with diverse cellular and …
to large gene-encoded peptides, that have evolved to provide them with diverse cellular and …
Strategies to access biosynthetic novelty in bacterial genomes for drug discovery
F Hemmerling, J Piel - Nature Reviews Drug Discovery, 2022 - nature.com
Bacteria provide a rich source of natural products with potential therapeutic applications,
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …
Artificial intelligence for natural product drug discovery
Developments in computational omics technologies have provided new means to access
the hidden diversity of natural products, unearthing new potential for drug discovery. In …
the hidden diversity of natural products, unearthing new potential for drug discovery. In …
Advances in decomposing complex metabolite mixtures using substructure-and network-based computational metabolomics approaches
Covering: up to the end of 2020 Recently introduced computational metabolome mining
tools have started to positively impact the chemical and biological interpretation of …
tools have started to positively impact the chemical and biological interpretation of …
Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entities
Covering: 2010 to 2021 Organisms in nature have evolved into proficient synthetic chemists,
utilizing specialized enzymatic machinery to biosynthesize an inspiring diversity of …
utilizing specialized enzymatic machinery to biosynthesize an inspiring diversity of …
Advanced methods for natural products discovery: bioactivity screening, dereplication, metabolomics profiling, genomic sequencing, databases and informatic tools …
Natural Products (NP) are essential for the discovery of novel drugs and products for
numerous biotechnological applications. The NP discovery process is expensive and time …
numerous biotechnological applications. The NP discovery process is expensive and time …
The chemistry of stress: understanding the 'cry for help'of plant roots
Plants are faced with various biotic and abiotic stresses during their life cycle. To withstand
these stresses, plants have evolved adaptive strategies including the production of a wide …
these stresses, plants have evolved adaptive strategies including the production of a wide …