For over a century, the importance of lipid metabolism in biology was recognized but difficult
to mechanistically understand due to the lack of sensitive and robust technologies for …

Lipids are amongst the most important organic compounds in living organisms, where they
serve as building blocks for cellular membranes as well as energy storage and signaling …

The detailed organization of cellular membranes remains rather elusive. Based on large-
scale molecular dynamics simulations, we provide a high-resolution view of the lipid …

The boost of research output in lipidomics during the last decade is tightly linked to improved
instrumentation in mass spectrometry. Associated with this trend is the shift from low …

In the last 2 decades, lipidomics has become one of the fastest expanding scientific
disciplines in biomedical research. With an increasing number of new research groups to …

Lipidomics is rapidly expanding because of the great facilitation of recent advances in, and
novel applications of, electrospray ionization mass spectrometry techniques. The greatest …

The field of lipidomics, as coined in 2003, has made profound advances and been rapidly
expanded. The mass spectrometry-based strategies of this analytical methodology-oriented …

The crucial role of lipids in cell, tissue and organ physiology is demonstrated by a large
number of genetic studies and by many human diseases that involve the disruption of lipid …

Once viewed simply as a reservoir for carbon storage, lipids are no longer cast as
bystanders in the drama of biological systems. The emerging field of lipidomics is driven by …

Single-cell analysis is critical to revealing cell-to-cell heterogeneity that would otherwise be
lost in ensemble analysis. Detailed lipidome characterization for single cells is still far from …