Notch signalling is involved in many aspects of cancer biology, including angiogenesis,
tumour immunity and the maintenance of cancer stem-like cells. In addition, Notch can …

The accumulation of genetic alterations in driver genes is responsible for the development
and malignant progression of colorectal cancer. Comprehensive genome analyses have …

The epithelial–mesenchymal transition (EMT) and cancer stem cell (CSC) formation are two
paramount processes driving tumor progression, therapy resistance, and cancer metastasis …

Notch has been implicated in human cancers and is a putative therapeutic target. However,
the regulation of Notch activation in the nucleus remains largely uncharacterized. Therefore …

Since their first discovery, investigations of colorectal cancer stem cells (CSCs) have
revealed some unexpected properties, including a high degree of heterogeneity and …

Pluripotency of embryonic stem cells (ESCs) and induced pluripotent stem cells is regulated
by a well characterized gene transcription circuitry. The circuitry is assembled by ESC …

Drug resistance is a major cause for therapeutic failure in non-small cell lung cancer
(NSCLC) leading to tumor recurrence and disease progression. Cell intrinsic mechanisms of …

Despite many advances and optimization in colon cancer treatment, tumor recurrence and
metastases make the development of new therapies necessary. Colon cancer stem cells …

Summary microRNAs regulate developmental cell-fate decisions, tissue homeostasis, and
oncogenesis in distinct ways relative to proteins. Here, we show that the tumor suppressor …

Aldehyde dehydrogenase (ALDH) is a candidate marker for lung cancer cells with stem cell-
like properties. Immunohistochemical staining of a large panel of primary non–small cell …