Ticket to a bubble ride: Cargo sorting into exosomes and extracellular vesicles
Extracellular vesicles (EVs) are released by cells into the extracellular milieu to facilitate
intercellular communication in both physiological and pathological condition. EVs contain …
intercellular communication in both physiological and pathological condition. EVs contain …
Ubiquitination and the regulation of membrane proteins
Newly synthesized transmembrane proteins undergo a series of steps to ensure that only
the required amount of correctly folded protein is localized to the membrane. The regulation …
the required amount of correctly folded protein is localized to the membrane. The regulation …
[HTML][HTML] The global phosphorylation landscape of SARS-CoV-2 infection
The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed …
respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed …
Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits
The genetic background of childhood body mass index (BMI), and the extent to which the
well-known associations of childhood BMI with adult diseases are explained by shared …
well-known associations of childhood BMI with adult diseases are explained by shared …
Mechanism of cargo sorting into small extracellular vesicles
Y Chen, Y Zhao, Y Yin, X Jia, L Mao - Bioengineered, 2021 - Taylor & Francis
Extracellular vesicles (EVs) are special membranous structures released by almost every
cell type that carry and protect some biomolecules from being degraded. They transport …
cell type that carry and protect some biomolecules from being degraded. They transport …
Changes in the coding and non-coding transcriptome and DNA methylome that define the Schwann cell repair phenotype after nerve injury
Repair Schwann cells play a critical role in orchestrating nerve repair after injury, but the
cellular and molecular processes that generate them are poorly understood. Here, we …
cellular and molecular processes that generate them are poorly understood. Here, we …
Drug-induced lactate confers ferroptosis resistance via p38-SGK1-NEDD4L-dependent upregulation of GPX4 in NSCLC cells
F Cheng, J Dou, Y Yang, S Sun, R Chen, Z Zhang… - Cell Death …, 2023 - nature.com
Ferroptosis is a newly defined non-apoptotic programmed cell death resulting from the
accumulation of lipid peroxides. Whether ferroptosis plays any role in chemotherapy …
accumulation of lipid peroxides. Whether ferroptosis plays any role in chemotherapy …
CircKDM4B suppresses breast cancer progression via the miR-675/NEDD4L axis
XY Guo, TT Liu, WJ Zhu, HT Liu, GH Zhang, L Song… - Oncogene, 2022 - nature.com
Increasing studies have indicated that circular RNAs (circRNAs) play pivotal roles in various
cancers. Here, we aimed to explore the roles of circRNAs in breast cancer. We identified a …
cancers. Here, we aimed to explore the roles of circRNAs in breast cancer. We identified a …
E3 ubiquitin ligases in cancer and implications for therapies
E3 ligases are a class of enzymes that can transfer ubiquitin to substrates for their
degradation, which are of importance in cellular homeostasis. Since many oncogenic or …
degradation, which are of importance in cellular homeostasis. Since many oncogenic or …
NEDD4L downregulates autophagy and cell growth by modulating ULK1 and a glutamine transporter
DE Lee, JE Yoo, J Kim, S Kim, S Kim, H Lee… - Cell death & …, 2020 - nature.com
In mammals, autophagosome formation is initiated by ULK1 via the posttranslational
modification of this protein. However, the precise role of ULK1 ubiquitination in modulating …
modification of this protein. However, the precise role of ULK1 ubiquitination in modulating …