Prostate cancer aggressiveness and metastatic potential are influenced by gene expression
and genomic aberrations, features that can be influenced by the 3D structure of …

Cells respond to double-strand breaks (DSBs) by activating DNA damage response
pathways, including cell cycle arrest. We have previously shown that a single double-strand …

The efficiency and outcome of CRISPR/Cas9 editing depends on the chromatin state at the
cut site. It has been shown that changing the chromatin state can influence both the …

Lamina-associated domains (LADs) are large chromatin regions that are associated with the
nuclear lamina (NL) and form a repressive environment for transcription. The molecular …

Historically considered downstream effects of tumorigenesis—arising from changes in DNA
content or chromatin organization—nuclear alterations have long been seen as mere …

Lamina-associated domains (LADs) are megabase-sized genomic regions that interact with
the nuclear lamina (NL). It is not yet understood how their interactions with the NL are …

The discovery of the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)
and its development as a genome editing tool has revolutionized the field of molecular …

The organization of the genome in three-dimensional space is highly dynamic, yet how
these dynamics are regulated and the role they play in genome function is poorly …

Lamina-associated domains (LADs) are megabase-sized genomic regions anchored to the
nuclear lamina (NL). Factors controlling the interactions of the genome with the NL have …

Pharmacoepigenomics is an emerging tool which complements pharmacogenetics in
personalized treatment. While pharmacogenetics refers to genetic variation in …