Chikungunya virus is widespread throughout the tropics, where it causes recurrent
outbreaks of chikungunya fever. In recent years, outbreaks have afflicted populations in East …

The recent proliferation of cryo-electron tomography (cryo-ET) techniques has led to the cryo-
ET resolution revolution. Meanwhile, significant efforts have been made to improve the …

Coronavirus replication is associated with the remodeling of cellular membranes, resulting
in the formation of double-membrane vesicles (DMVs). A DMV-spanning pore was identified …

Coronaviruses remodel the intracellular host membranes during replication, forming double-
membrane vesicles (DMVs) to accommodate viral RNA synthesis and modifications,. SARS …

Alphaviruses, such as chikungunya virus (CHIKV), are mosquito-borne viruses that
represent a significant threat to human health due to the current context of global warming …

RNA viruses rapidly adapt to selective conditions due to the high intrinsic mutation rates of
their RNA-dependent RNA polymerases (RdRps). Insertions and deletions (indels) in viral …

Positive-strand RNA viruses encompass a variety of established and emerging eukaryotic
pathogens. Their genome replication is confined to specialized cytoplasmic membrane …

Replicating RNA, including self-amplifying RNA (saRNA) and trans-amplifying RNA
(taRNA), holds great potential for advancing the next generation of RNA-based vaccines …

Cryo-electron tomography (cryo-ET) allows high resolution 3D imaging of biological
samples in near-native environments. Thus, cryo-ET has become the method of choice to …

The alphaviruses are a widely distributed group of positive-sense, single stranded, RNA
viruses. These viruses are largely arthropod-borne and can be found on all populated …