The human connectome in Alzheimer disease—relationship to biomarkers and genetics

M Yu, O Sporns, AJ Saykin - Nature Reviews Neurology, 2021 - nature.com
The pathology of Alzheimer disease (AD) damages structural and functional brain networks,
resulting in cognitive impairment. The results of recent connectomics studies have now …

Using the Alzheimer's Disease Neuroimaging Initiative to improve early detection, diagnosis, and treatment of Alzheimer's disease

DP Veitch, MW Weiner, PS Aisen… - Alzheimer's & …, 2022 - Wiley Online Library
Abstract Introduction The Alzheimer's Disease Neuroimaging Initiative (ADNI) has
accumulated 15 years of clinical, neuroimaging, cognitive, biofluid biomarker and genetic …

Multimodal deep learning models for early detection of Alzheimer's disease stage

J Venugopalan, L Tong, HR Hassanzadeh… - Scientific reports, 2021 - nature.com
Most current Alzheimer's disease (AD) and mild cognitive disorders (MCI) studies use single
data modality to make predictions such as AD stages. The fusion of multiple data modalities …

Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease

JW Vogel, Y Iturria-Medina, OT Strandberg… - Nature …, 2020 - nature.com
Tau is a hallmark pathology of Alzheimer's disease, and animal models have suggested that
tau spreads from cell to cell through neuronal connections, facilitated by β-amyloid (A β). We …

Metabolic network analysis reveals altered bile acid synthesis and metabolism in Alzheimer's disease

P Baloni, CC Funk, J Yan, JT Yurkovich… - Cell Reports …, 2020 - cell.com
Increasing evidence suggests Alzheimer's disease (AD) pathophysiology is influenced by
primary and secondary bile acids, the end product of cholesterol metabolism. We analyze …

Accelerated functional brain aging in pre-clinical familial Alzheimer's disease

J Gonneaud, AT Baria, A Pichet Binette… - Nature …, 2021 - nature.com
Resting state functional connectivity (rs-fMRI) is impaired early in persons who subsequently
develop Alzheimer's disease (AD) dementia. This impairment may be leveraged to aid …

INTREPAD: A randomized trial of naproxen to slow progress of presymptomatic Alzheimer disease

PF Meyer, J Tremblay-Mercier, J Leoutsakos… - Neurology, 2019 - AAN Enterprises
Objective To evaluate the safety and efficacy of low-dose naproxen for prevention of
progression in presymptomatic Alzheimer disease (AD) among cognitively intact persons at …

[HTML][HTML] Open science datasets from PREVENT-AD, a longitudinal cohort of pre-symptomatic Alzheimer's disease

J Tremblay-Mercier, C Madjar, S Das, AP Binette… - NeuroImage: Clinical, 2021 - Elsevier
Abstract To move Alzheimer Disease (AD) research forward it is essential to collect data
from large cohorts, but also make such data available to the global research community. We …

The road to personalized medicine in Alzheimer's disease: the use of artificial intelligence

A Silva-Spínola, I Baldeiras, JP Arrais, I Santana - Biomedicines, 2022 - mdpi.com
Dementia remains an extremely prevalent syndrome among older people and represents a
major cause of disability and dependency. Alzheimer's disease (AD) accounts for the …

[HTML][HTML] Modelling prognostic trajectories of cognitive decline due to Alzheimer's disease

J Giorgio, SM Landau, WJ Jagust, P Tino, Z Kourtzi… - NeuroImage: Clinical, 2020 - Elsevier
Alzheimer's disease (AD) is characterised by a dynamic process of neurocognitive changes
from normal cognition to mild cognitive impairment (MCI) and progression to dementia …