The human connectome in Alzheimer disease—relationship to biomarkers and genetics
The pathology of Alzheimer disease (AD) damages structural and functional brain networks,
resulting in cognitive impairment. The results of recent connectomics studies have now …
resulting in cognitive impairment. The results of recent connectomics studies have now …
Using the Alzheimer's Disease Neuroimaging Initiative to improve early detection, diagnosis, and treatment of Alzheimer's disease
DP Veitch, MW Weiner, PS Aisen… - Alzheimer's & …, 2022 - Wiley Online Library
Abstract Introduction The Alzheimer's Disease Neuroimaging Initiative (ADNI) has
accumulated 15 years of clinical, neuroimaging, cognitive, biofluid biomarker and genetic …
accumulated 15 years of clinical, neuroimaging, cognitive, biofluid biomarker and genetic …
Multimodal deep learning models for early detection of Alzheimer's disease stage
Most current Alzheimer's disease (AD) and mild cognitive disorders (MCI) studies use single
data modality to make predictions such as AD stages. The fusion of multiple data modalities …
data modality to make predictions such as AD stages. The fusion of multiple data modalities …
Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease
Tau is a hallmark pathology of Alzheimer's disease, and animal models have suggested that
tau spreads from cell to cell through neuronal connections, facilitated by β-amyloid (A β). We …
tau spreads from cell to cell through neuronal connections, facilitated by β-amyloid (A β). We …
Metabolic network analysis reveals altered bile acid synthesis and metabolism in Alzheimer's disease
Increasing evidence suggests Alzheimer's disease (AD) pathophysiology is influenced by
primary and secondary bile acids, the end product of cholesterol metabolism. We analyze …
primary and secondary bile acids, the end product of cholesterol metabolism. We analyze …
Accelerated functional brain aging in pre-clinical familial Alzheimer's disease
Resting state functional connectivity (rs-fMRI) is impaired early in persons who subsequently
develop Alzheimer's disease (AD) dementia. This impairment may be leveraged to aid …
develop Alzheimer's disease (AD) dementia. This impairment may be leveraged to aid …
INTREPAD: A randomized trial of naproxen to slow progress of presymptomatic Alzheimer disease
Objective To evaluate the safety and efficacy of low-dose naproxen for prevention of
progression in presymptomatic Alzheimer disease (AD) among cognitively intact persons at …
progression in presymptomatic Alzheimer disease (AD) among cognitively intact persons at …
[HTML][HTML] Open science datasets from PREVENT-AD, a longitudinal cohort of pre-symptomatic Alzheimer's disease
Abstract To move Alzheimer Disease (AD) research forward it is essential to collect data
from large cohorts, but also make such data available to the global research community. We …
from large cohorts, but also make such data available to the global research community. We …
The road to personalized medicine in Alzheimer's disease: the use of artificial intelligence
A Silva-Spínola, I Baldeiras, JP Arrais, I Santana - Biomedicines, 2022 - mdpi.com
Dementia remains an extremely prevalent syndrome among older people and represents a
major cause of disability and dependency. Alzheimer's disease (AD) accounts for the …
major cause of disability and dependency. Alzheimer's disease (AD) accounts for the …
[HTML][HTML] Modelling prognostic trajectories of cognitive decline due to Alzheimer's disease
Alzheimer's disease (AD) is characterised by a dynamic process of neurocognitive changes
from normal cognition to mild cognitive impairment (MCI) and progression to dementia …
from normal cognition to mild cognitive impairment (MCI) and progression to dementia …