Currently microorganisms are best identified using 16S rRNA and 18S rRNA gene
sequencing. However, in recent years matrix assisted laser desorption ionization-time of …

This review provides a state-of-the-art description of the performance of Sanger cycle
sequencing of the 16S rRNA gene for routine identification of bacteria in the clinical …

Glioblastomas are malignant tumors of the central nervous system hallmarked by subclonal
diversity and dynamic adaptation amid developmental hierarchies. The source of dynamic …

Detection of SARS-CoV-2 using RT–PCR and other advanced methods can achieve high
accuracy. However, their application is limited in countries that lack sufficient resources to …

The dynamics and phenotypes of intratumoral myeloid cells during tumor progression are
poorly understood. Here we define myeloid cellular states in gliomas by longitudinal single …

Mass spectrometry (MS) has become a central technique in cancer research. The ability to
analyze various types of biomolecules in complex biological matrices makes it well suited for …

Imaging mass spectrometry (IMS) is a rapidly advancing molecular imaging modality that
can map the spatial distribution of molecules with high chemical specificity. IMS does not …

Tumors are intrinsically heterogeneous and it is well established that this directs their
evolution, hinders their classification and frustrates therapy,–. Consequently, spatially …

Gastric cancer (GC) presents high mortality worldwide because of delayed diagnosis.
Currently, exosome-based liquid biopsy has been applied in diagnosis and monitoring of …

Genetic and fragmented palaeoanthropological data suggest that Denisovans were once
widely distributed across eastern Eurasia,–. Despite limited archaeological evidence, this …