Critical care, like many healthcare areas, is under a dual assault from significantly
increasing demographic and economic pressures. Intensive care unit (ICU) patients are …

This paper explores the use of biomechanics in identifying the mechanistic causes of
musculoskeletal tissue injury and degeneration. It appraises how biomechanics has been …

Abstract Background and Objective: Cardiac electrophysiology is a medical specialty with a
long and rich tradition of computational modeling. Nevertheless, no community standard for …

We present version 3 of the open-source simulator for flow and transport processes in
porous media DuMu x. DuMu x is based on the modular C++ framework Dune (Distributed …

Chaste—C ancer, H eart A nd S oft T issue E nvironment—is an open source C++ library for
the computational simulation of mathematical models developed for physiology and biology …

By its very nature, research into multi-physical processes occurring in porous and fractured
media requires a collaborative approach. An interdisciplinary approach has led to the …

Herein, state‐of‐the‐art multiscale modeling methods have been described. This research
includes notable molecular, micro‐, meso‐, and macroscale models for hard (polymer …

Abstract Background and Objective: Myocardial infarction (MI) is a myocardial anoxic
incapacitation caused by severe cardiovascular obstruction that can cause irreversible injury …

Models of cardiac mechanics are increasingly used to investigate cardiac physiology. These
models are characterized by a high level of complexity, including the particular anisotropic …

Human physiological functions are regulated across many orders of magnitude in space and
time. Integrating the information and dynamics from one scale to another is critical for the …