Limonoids from neem (Azadirachta indica A. Juss.) are potential anticancer drug candidates

S Nagini, M Palrasu, A Bishayee - Medicinal research reviews, 2024 - Wiley Online Library
Abstract Neem (Azadirachta indica A. Juss.), a versatile evergreen tree recognized for its
ethnopharmacological value, is a rich source of limonoids of the triterpenoid class, endowed …

Research progress of meliaceous limonoids from 2011 to 2021

J Luo, Y Sun, Q Li, L Kong - Natural Product Reports, 2022 - pubs.rsc.org
Covering: July 2010 to December 2021 Limonoids, a kind of natural tetranortriterpenoids
with diverse skeletons and valuable insecticidal and medicinal bioactivities, are the …

Vitamin metal–organic framework-laden microfibers from microfluidics for wound healing

Y Yu, G Chen, J Guo, Y Liu, J Ren, T Kong… - Materials Horizons, 2018 - pubs.rsc.org
Vitamin MOF-laden microfibers with alginate shells and copper-or zinc-vitamin framework
cores are controllably generated by using a coaxial capillary microfluidic spinning approach …

Nimbolide, a neem limonoid inhibits cytoprotective autophagy to activate apoptosis via modulation of the PI3K/Akt/GSK-3β signalling pathway in oral cancer

J Sophia, J Kowshik, A Dwivedi, SK Bhutia… - Cell death & …, 2018 - nature.com
Of late, nimbolide, a limonoid from the neem tree (Azadirachta indica) has gained increasing
research attention owing to its potent antiproliferative and apoptosis-inducing effects. The …

Plant-based antioxidant extracts and compounds in the management of oral cancer

S Prakash, Radha, M Kumar, N Kumari, M Thakur… - Antioxidants, 2021 - mdpi.com
Oral cancer continues to be a leading cause of death worldwide, and its prevalence is
particularly high in develo** countries, where people chew tobacco and betel nut on a …

Phytochemicals mediated modulation of microRNAs and long non‐coding RNAs in cancer prevention and therapy

LM Ruiz‐Manriquez, C Estrada‐Meza… - Phytotherapy …, 2022 - Wiley Online Library
MicroRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are two main categories of
noncoding RNAs (ncRNAs) that can influence essential biological functions in various ways …

Nimbolide, a neem limonoid, is a promising candidate for the anticancer drug arsenal

S Nagini, R Nivetha, M Palrasu… - Journal of medicinal …, 2021 - ACS Publications
Nimbolide, a major limonoid constituent of Azadirachta indica, commonly known as neem,
has attracted increasing research attention owing to its wide spectrum of pharmacological …

Bcl-xL expression and regulation in the progression, recurrence, and cisplatin resistance of oral cancer

M Alam, R Mishra - Life sciences, 2021 - Elsevier
Background Bcl-xL is an anti-apoptotic molecule, but its role in the progression and
recurrent/drug-resistant oral squamous cell carcinoma (OSCC) is poorly understood …

A review of the anticancer activity of Azadirachta indica (Neem) in oral cancer

S Agrawal, DB Popli, K Sircar, A Chowdhry - Journal of Oral Biology and …, 2020 - Elsevier
Background Azadirachta indica (neem), belongs to the family of Meliaceae plants, is found
in the Indian subcontinent. The neem tree is colloquially referred to as the village pharmacy …

Phytochemicals modulate cancer aggressiveness: A review depicting the anticancer efficacy of dietary polyphenols and their combinations

T Mitra, R Bhattacharya - Journal of Cellular Physiology, 2020 - Wiley Online Library
Cancer is referred to as the “Emperor of all maladies” accounting for the second‐highest
mortality rates worldwide. Major factors associated with cancer lethality are uncontrolled …