Cotranslational protein folding depends on general chaperones that engage highly diverse
nascent chains at the ribosomes. Here we discover a dedicated ribosome-associated …

Eukaryotic translation elongation factor 1A (eEF1A) is a highly abundant, multi-domain
GTPase. Post-translational steps essential for eEF1A biogenesis are carried out by bespoke …

Protein homeostasis (proteostasis) refers to the balance between protein production, folding,
and degradation, and is coordinated by components of the proteostasis network. Preserving …

Protein folding and assembly is aided by molecular chaperones that prevent aggregation of
unfolded or partially folded intermediates and guide them to their native folded state …