Transcription factors (TFs) are key regulatory proteins that control the transcriptional rate of
cells by binding short DNA sequences called transcription factor binding sites (TFBS) or …

Abstract The 2022 Nucleic Acids Research Database Issue contains 185 papers, including
87 papers reporting on new databases and 85 updates from resources previously published …

Transcription factors (TFs) can regulate gene expression by recognizing specific cis-
regulatory elements in DNA sequences. TF-DNA binding prediction has become a …

RNA-binding proteins (RBPs) play key roles in a wide range of physiological and
pathological processes. To facilitate the investigation of RBP functions and disease …

In mammals, transcriptional factors (TFs) drive gene expression by binding to regulatory
elements in a cooperative manner. Deciphering the rules of such cooperation is crucial to …

Breast cancer is a complex disease that is influenced by the concurrent influence of multiple
genetic and environmental factors. Recent advances in genomics and other high throughput …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder with profound global
impact. While genome-wide association studies (GWAS) have revealed genomic variants …

Cofactors interacting with PPARγ can regulate adipogenesis and adipocyte metabolism by
modulating the transcriptional activity and selectivity of PPARγ signaling. ZFP407 was …

Biologically precise enhancer licensing by lineage-determining transcription factors enables
activation of transcripts appropriate to biological demand and prevents deleterious gene …

Endometritis is an inflammatory disease that negatively influences fertility and is common in
milk-producing cows. An in vitro model for bovine endometrial inflammation was used to …