Cytokines are critical in regulating immune responses and cellular behavior, playing dual
roles in both normal physiology and the pathology of diseases such as cancer. These …

Metastasis remains a pivotal characteristic of cancer and is the primary contributor to cancer-
associated mortality. Despite its significance, the mechanisms governing metastasis are not …

Pancreatic cancer is a major cause of cancer-related death, but despondently, the outlook
and prognosis for this resistant type of tumor have remained grim for a long time. Currently, it …

The therapeutic potential of interleukin (IL)-2 in cancer treatment has been known for
decades, yet its widespread adoption in clinical practice remains limited. Recently, chimeric …

The cascade of metastasis in tumor cells, exhibiting organ-specific tendencies, may occur at
numerous phases of the disease and progress under intense evolutionary pressures. Organ …

CD8+ T cell immune responses are regulated by multi-layer networks, while the post-
translational regulation remains largely unknown. Transmembrane ectodomain shedding is …

Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is characterized by a highly
desmoplastic and extreme immunosuppressive tumor microenvironment (TME), which …

Background Perineural invasion (PNI) and nerve density within the tumor microenvironment
(TME) have long been associated with worse outcomes in head and neck squamous cell …

The RNA N 6-methyladenosine (m6A) reader YTHDF1 is implicated in cancer etiology and
progression. We discovered that radiotherapy (RT) increased YTHDF1 expression in …

Cancer vaccines drive the activation and proliferation of tumor-reactive immune cells,
thereby eliciting tumor-specific immunity that kills tumor cells. Accordingly, they possess …