Traumatic brain injury rapidly induces inflammation. This inflammation is produced both by
endogenous brain cells and circulating inflammatory cells that enter from the brain. Together …

The hypothalamic-pituitary-adrenal (HPA) axis is one of the most important allostatic
systems that allow a person to respond and adapt against diverse stresses by upregulating …

Cerebral inflammation and apoptotic cell death are two processes implicated in the
progressive tissue damage that occurs following traumatic brain injury (TBI), and strategies …

The International Mission on Prognosis and Analysis of Clinical Trials in Traumatic Brain
Injury (IMPACT) and Corticoid Randomisation After Significant Head injury (CRASH) …

Background Conducting research in critically-ill patient populations is challenging, and most
randomized trials of critically-ill patients have not achieved pre-specified statistical …

Traumatic brain injury is one of the leading causes of morbidity and mortality worldwide and
is one of the major public healthcare burdens in the US, with millions of patients suffering …

Study Design: Narrative review. Objectives: To provide an updated overview of the
management of acute traumatic central cord syndrome (ATCCS). Methods: A …

The aim of this article is to evaluate current literature on investigation and management of
traumatic optic neuropathy (TON), propose recommendations for diagnosis and …

Spontaneous intracerebral hemorrhage (ICH) is the deadliest stroke subtype and
neuroinflammation is a critical component of the pathogenesis following ICH. Annexin A1 …

Despite the fact that neutrophils are essential for the protection from invading pathogens,
hyperactive neutrophils may elicit detrimental cerebral damage after severe trauma. The …