Applicability of scrape loading-dye transfer assay for non-genotoxic carcinogen testing
I Sovadinová, BL Upham, JE Trosko… - International Journal of …, 2021 - mdpi.com
Dysregulation of gap junction intercellular communication (GJIC) is recognized as one of the
key hallmarks for identifying non-genotoxic carcinogens (NGTxC). Currently, there is a …
key hallmarks for identifying non-genotoxic carcinogens (NGTxC). Currently, there is a …
Activation of the aryl hydrocarbon receptor is the major toxic mode of action of an organic extract of a reference urban dust particulate matter mixture: the role of …
Many of the toxic and carcinogenic effects of urban air pollution have been linked to
polycyclic aromatic hydrocarbons (PAHs) adsorbed to airborne particulate matter (PM). The …
polycyclic aromatic hydrocarbons (PAHs) adsorbed to airborne particulate matter (PM). The …
Consensus Toxicity Factors for Polychlorinated Dibenzo-p-dioxins, Dibenzofurans, and Biphenyls Combining in Silico Models and Extensive in Vitro Screening of …
M Larsson, M van den Berg, P Brenerová… - Chemical research in …, 2015 - ACS Publications
Consensus toxicity factors (CTFs) were developed as a novel approach to establish toxicity
factors for risk assessment of dioxin-like compounds (DLCs). Eighteen polychlorinated …
factors for risk assessment of dioxin-like compounds (DLCs). Eighteen polychlorinated …
The aryl hydrocarbon receptor-dependent deregulation of cell cycle control induced by polycyclic aromatic hydrocarbons in rat liver epithelial cells
Disruption of cell proliferation control by polycyclic aromatic hydrocarbons (PAHs) may
contribute to their carcinogenicity. We investigated role of the aryl hydrocarbon receptor …
contribute to their carcinogenicity. We investigated role of the aryl hydrocarbon receptor …
Concentrations of methylated naphthalenes, anthracenes, and phenanthrenes occurring in Czech river sediments and their effects on toxic events associated with …
J Vondráĉek, L Ŝvihálková‐Ŝindlerová… - … and Chemistry: An …, 2007 - Wiley Online Library
Alkylated polycyclic aromatic hydrocarbons (PAHs) are important environmental pollutants.
In the present study, we determined levels of monomethylated naphthalenes (MeNap) …
In the present study, we determined levels of monomethylated naphthalenes (MeNap) …
The aryl hydrocarbon receptor-mediated and genotoxic effects of fractionated extract of standard reference diesel exhaust particle material in pulmonary, liver and …
L Pálková, J Vondráček, L Trilecová, M Ciganek… - Toxicology in Vitro, 2015 - Elsevier
Diesel exhaust particles (DEP) and the associated complex mixtures of organic pollutants,
such as polycyclic aromatic hydrocarbons (PAHs), or their derivatives, have been suggested …
such as polycyclic aromatic hydrocarbons (PAHs), or their derivatives, have been suggested …
Deregulation of signaling pathways controlling cell survival and proliferation in cancer cells alters induction of cytochrome P450 family 1 enzymes
M Krkoška, J Svobodová, M Kabátková, O Zapletal… - Toxicology, 2021 - Elsevier
Abstract Cytochrome P450 family 1 (CYP1) enzymes contribute both to metabolism of
xenobiotics and to the control of endogenous levels of ligands of the aryl hydrocarbon …
xenobiotics and to the control of endogenous levels of ligands of the aryl hydrocarbon …
DNA adducts formation and induction of apoptosis in rat liver epithelial 'stem-like'cells exposed to carcinogenic polycyclic aromatic hydrocarbons
J Topinka, S Marvanová, J Vondráček… - Mutation Research …, 2008 - Elsevier
The bipotent liver progenitor cells, so called oval cells, may participate at the early stages of
hepatocarcinogenesis induced by chemical carcinogens. Unlike in mature parenchymal …
hepatocarcinogenesis induced by chemical carcinogens. Unlike in mature parenchymal …
Toxic Effects of Methylated Benz[a]anthracenes in Liver Cells
S Marvanová, J Vondráček… - Chemical research in …, 2008 - ACS Publications
Monomethylated benz [a] anthracenes (MeBaAs) are an important group of methylated
derivatives of polycyclic aromatic hydrocarbons (PAHs). Although the methyl substitution …
derivatives of polycyclic aromatic hydrocarbons (PAHs). Although the methyl substitution …
Theoretical evaluation of interaction of some dibenzo derivatives on both androgen receptor and 5α-reductase enzyme
L Figueroa-Valverde, M Rosas-Nexticapa… - Clinical Cancer …, 2022 - ccij-online.org
There are several drugs to treat cancer; nevertheless, some can produce adverse effects,
such as hypertension, hepatic injury, and erectile dysfunction. In the search for new …
such as hypertension, hepatic injury, and erectile dysfunction. In the search for new …