NAD+ homeostasis in health and disease
The conceptual evolution of nicotinamide adenine dinucleotide (NAD+) from being seen as
a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and …
a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and …
Natural products: potential treatments for cisplatin-induced nephrotoxicity
C Fang, D Lou, L Zhou, J Wang, B Yang, Q He… - Acta Pharmacologica …, 2021 - nature.com
Cisplatin is a clinically advanced and highly effective anticancer drug used in the treatment
of a wide variety of malignancies, such as head and neck, lung, testis, ovary, breast cancer …
of a wide variety of malignancies, such as head and neck, lung, testis, ovary, breast cancer …
Curcumin and its derivatives in cancer therapy: Potentiating antitumor activity of cisplatin and reducing side effects
Curcumin is a phytochemical isolated from Curcuma longa with potent tumor‐suppressor
activity, which has shown significant efficacy in pre‐clinical and clinical studies. Curcumin …
activity, which has shown significant efficacy in pre‐clinical and clinical studies. Curcumin …
Therapeutic potential of NAD-boosting molecules: the in vivo evidence
Nicotinamide adenine dinucleotide (NAD), the cell's hydrogen carrier for redox enzymes, is
well known for its role in redox reactions. More recently, it has emerged as a signaling …
well known for its role in redox reactions. More recently, it has emerged as a signaling …
Natural product interventions for chemotherapy and radiotherapy-induced side effects
QY Zhang, FX Wang, KK Jia, LD Kong - Frontiers in pharmacology, 2018 - frontiersin.org
Cancer is the second leading cause of death in the world. Chemotherapy and radiotherapy
are the common cancer treatments. However, the development of adverse effects resulting …
are the common cancer treatments. However, the development of adverse effects resulting …
Oxidant mechanisms in renal injury and disease
BB Ratliff, W Abdulmahdi, R Pawar… - Antioxidants & redox …, 2016 - liebertpub.com
Significance: A common link between all forms of acute and chronic kidney injuries,
regardless of species, is enhanced generation of reactive oxygen species (ROS) and …
regardless of species, is enhanced generation of reactive oxygen species (ROS) and …
Sirtuins, a promising target in slowing down the ageing process
W Grabowska, E Sikora, A Bielak-Zmijewska - Biogerontology, 2017 - Springer
Ageing is a plastic process and can be successfully modulated by some biomedical
approaches or pharmaceutics. In this manner it is possible to delay or even prevent some …
approaches or pharmaceutics. In this manner it is possible to delay or even prevent some …
Role of nicotinamide adenine dinucleotide and related precursors as therapeutic targets for age-related degenerative diseases: rationale, biochemistry …
Significance: Nicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide
that serves as an essential cofactor and substrate for a number of critical cellular processes …
that serves as an essential cofactor and substrate for a number of critical cellular processes …
Curcumin–cisplatin chemotherapy: A novel strategy in promoting chemotherapy efficacy and reducing side effects
The efficacy of chemotherapy in cancer therapy is limited due to resistance, treatment
selectivity, and severe adverse effects. Immunotherapy, chemotherapy, targeted therapy …
selectivity, and severe adverse effects. Immunotherapy, chemotherapy, targeted therapy …
Role of NAD+ and mitochondrial sirtuins in cardiac and renal diseases
The coenzyme nicotinamide adenine dinucleotide (NAD+) has key roles in the regulation of
redox status and energy metabolism. NAD+ depletion is emerging as a major contributor to …
redox status and energy metabolism. NAD+ depletion is emerging as a major contributor to …