Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions

P Rasoanaivo, CW Wright, ML Willcox, B Gilbert - Malaria journal, 2011 - Springer
Background In traditional medicine whole plants or mixtures of plants are used rather than
isolated compounds. There is evidence that crude plant extracts often have greater in vitro …

[HTML][HTML] Plant-derived antimalarial agents: new leads and efficient phytomedicines. Part II. Non-alkaloidal natural products

R Batista, A De Jesus Silva Júnior, AB De Oliveira - Molecules, 2009 - mdpi.com
Malaria is still the most destructive and dangerous parasitic infection in many tropical and
subtropical countries. The burden of this disease is getting worse, mainly due to the …

[HTML][HTML] Screening for natural and derived bio-active compounds in preclinical and clinical studies: One of the frontlines of fighting the coronaviruses pandemic

SAM Khalifa, N Yosri, MF El-Mallah, R Ghonaim, Z Guo… - Phytomedicine, 2021 - Elsevier
Abstract Background Starting December 2019, mankind faced an unprecedented enemy,
the COVID-19 virus. The world convened in international efforts, experiences and …

In vivo antimalarial activity of the crude leaf extract and solvent fractions of Croton macrostachyus Hocsht. (Euphorbiaceae) against Plasmodium berghei in mice

L Bantie, S Assefa, T Teklehaimanot… - BMC complementary and …, 2014 - Springer
Background The issue of resistance in malarial infection makes development of novel drugs
a necessity. An alternative source for discovering such drugs is natural products. Croton …

In vitro antiplasmodial effect of ethanolic extracts of traditional medicinal plant Ocimum species against Plasmodium falciparum

SJ Inbaneson, R Sundaram, P Suganthi - Asian Pacific Journal of tropical …, 2012 - Elsevier
OBJECTIVE: To identify the possible antiplasmodial compounds from leaf, stem, root and
flower extracts of Ocimum canum (O. canum), Ocimum sanctum (O. sanctum) and Ocimum …

[HTML][HTML] A literature review on traditional herbal medicines for malaria

M Noronha, V Pawar, A Prajapati… - South African Journal of …, 2020 - Elsevier
Malaria is known to cause around 1 million deaths per annum. This life-threatening disease
is mostly prevalent in Africa. Due to the burgeoning problem of drug resistance, it is getting …

Naphthylisoquinoline alkaloids potential drug leads

SRM Ibrahim, GA Mohamed - Fitoterapia, 2015 - Elsevier
Naphthylisoquinolines are a group of structurally diverse secondary metabolites, consisting
of naphthalene and isoquinoline moieties. Naturally occurring naphthylisoquinolines have …

Efficacy of lapachol on treatment of cutaneous and visceral leishmaniasis

IAC Araújo, RC de Paula, CL Alves, KF Faria… - Experimental …, 2019 - Elsevier
Leishmaniasis is one of the most important neglected diseases worldwide. It is a life-
threatening disease and causes significant morbidity, long-term disability, and early death …

[HTML][HTML] Identification of plumbagin and sanguinarine as effective chemotherapeutic agents for treatment of schistosomiasis

SM Zhang, KA Coultas - International Journal for Parasitology: Drugs and …, 2013 - Elsevier
Schistosomiasis, a snail-borne parasitic disease, affects more than 200 million people
worldwide. Currently the treatment of schistosomiasis relies on a single therapy of …

Antimalarial activity of crude extract and solvent fractions of the leaves of Bersama abyssinica fresen.(Melianthaceae) against Plasmodium berghei infection in Swiss …

AA Alehegn, JS Yesuf, EM Birru - … ‐Based Complementary and …, 2020 - Wiley Online Library
Background. Treatment of malaria has been compromised by the emergence of drug‐
resistant parasites. Consequently, novel agents are urgently needed from different sources …