Hypoxia is an environmental stressor that is instigated by low oxygen availability. It fuels the
progression of solid tumors by driving tumor plasticity, heterogeneity, stemness and genomic …

Metastasis is a major clinical problem and results in a poor prognosis for most cancers. The
metastatic pathway describes the process by which cancer cells give rise to a metastatic …

Angiogenesis is the process of new blood vessel formation, regulated by a number of pro-
and antiangiogenic factors and usually begins in response to hypoxia. Exogenous …

Introduction The immunosuppressive tumor microenvironment (TME) of solid tumors inhibits
most drug delivery system-based nanomaterials from achieving deep penetration in tumor …

Reciprocal growth factor exchange between endothelial and malignant cells within the
tumor microenvironment may directly stimulate neovascularization; however, the role of host …

Reciprocal growth factor exchanges between endothelial and malignant cells within the
hypoxic microenvironment determine tumor progression. However, the nature of these …

[Frontiers in Bioscience S3, 946-960, June 1, 2011] 946 Endothelial dysfunction in hypertension:
The role of arginase Danielle L Page 1 [Frontiers in Bioscience S3, 946-960, June 1, 2011] 946 …

New Platinum and Ruthenium complexes display antitumour and antimetastatic potentials
and lower host toxicities. This mini-review examines some the more recent developments in …

Background Cancer increases the risk of venous thromboembolism, and glioblastoma is one
of the cancer types with the highest risk of venous thromboembolism (10%-30%). Tumor …

Aging has become a significant risk factor for several diseases, including breast cancer.
Platelet activation and platelet-cancer cell aggregate fractions were found to increase with …