Principles of targeting endothelial cell metabolism to treat angiogenesis and endothelial cell dysfunction in disease

J Goveia, P Stapor, P Carmeliet - EMBO molecular medicine, 2014 - embopress.org
The endothelium is the orchestral conductor of blood vessel function. Pathological blood
vessel formation (a process termed pathological angiogenesis) or the inability of endothelial …

Beta-aminoisobutyric acid as a novel regulator of carbohydrate and lipid metabolism

DA Tanianskii, N Jarzebska, AL Birkenfeld… - Nutrients, 2019 - mdpi.com
The prevalence and incidence of metabolic syndrome is reaching pandemic proportions
worldwide, thus warranting an intensive search for novel preventive and treatment …

Attenuation of clinical and immunological outcomes during SARS‐CoV‐2 infection by ivermectin

GD de Melo, F Lazarini, F Larrous, L Feige… - EMBO molecular …, 2021 - embopress.org
The devastating pandemic due to SARS‐CoV‐2 and the emergence of antigenic variants
that jeopardize the efficacy of current vaccines create an urgent need for a comprehensive …

Assessing the causal association of glycine with risk of cardio-metabolic diseases

LBL Wittemans, LA Lotta, C Oliver-Williams… - Nature …, 2019 - nature.com
Circulating levels of glycine have previously been associated with lower incidence of
coronary heart disease (CHD) and type 2 diabetes (T2D) but it remains uncertain if glycine …

The role of amino acids in endothelial biology and function

M Li, Y Wu, L Ye - Cells, 2022 - mdpi.com
The vascular endothelium acts as an important component of the vascular system. It is a
barrier between the blood and vessel wall. It plays an important role in regulating blood …

Glycine regulates mucosal immunity and the intestinal microbial composition in weaned piglets

Y Ji, X Fan, Y Zhang, J Li, Z Dai, Z Wu - Amino Acids, 2022 - Springer
Glycine is an amino acid with a diverse array of health benefits regarding metabolism,
immunity, and development. The aim of this study was to test the hypothesis that glycine …

[HTML][HTML] Fermented Fish Collagen Attenuates Melanogenesis via Decreasing UV-Induced Oxidative Stress

KA Byun, SY Lee, S Oh, S Batsukh, JW Jang, BJ Lee… - Marine Drugs, 2024 - mdpi.com
Excessive melanogenesis leads to hyperpigmentation-related cosmetic problems. UV
exposure increases oxidative stress, which promotes melanogenesis-related signal …

Effects of glycine on metabolic syndrome components: a review

M Imenshahidi, H Hossenzadeh - Journal of Endocrinological …, 2022 - Springer
Purpose Glycine is the simplest and major amino acid in humans. It is mainly generated in
the liver and kidney and is used to produce collagen, creatine, glucose and purine. It is also …

Role of neurochemicals in the interaction between the microbiota and the immune and the nervous system of the host organism

AV Oleskin, BA Shenderov, VS Rogovsky - Probiotics and Antimicrobial …, 2017 - Springer
This work is concerned with the role of evolutionary conserved substances,
neurotransmitters, and neurohormones, within the complex framework of the microbial …

Impaired “glycine”-mia in type 2 diabetes and potential mechanisms contributing to glucose homeostasis

R Yan-Do, PE MacDonald - Endocrinology, 2017 - academic.oup.com
The onset and/or progression of type 2 diabetes (T2D) can be prevented if intervention is
early enough. As such, much effort has been placed on the search for indicators predictive of …