Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences
N Exner, AK Lutz, C Haass, KF Winklhofer - The EMBO journal, 2012 - embopress.org
Neurons are critically dependent on mitochondrial integrity based on specific morphological,
biochemical, and physiological features. They are characterized by high rates of metabolic …
biochemical, and physiological features. They are characterized by high rates of metabolic …
The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease
MR Cookson - Nature Reviews Neuroscience, 2010 - nature.com
Parkinson's disease, like many common age-related conditions, is now recognized to have a
substantial genetic component. Here, I discuss how mutations in a large complex gene …
substantial genetic component. Here, I discuss how mutations in a large complex gene …
Ser1292 Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations
Z Sheng, S Zhang, D Bustos, T Kleinheinz… - Science translational …, 2012 - science.org
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common cause of
familial Parkinson's disease (PD). Although biochemical studies have shown that certain PD …
familial Parkinson's disease (PD). Although biochemical studies have shown that certain PD …
Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser910/Ser935, disruption of 14-3-3 binding and altered cytoplasmic localization
LRRK2 (leucine-rich repeat protein kinase 2) is mutated in a significant number of
Parkinson's disease patients. Since a common mutation that replaces Gly2019 with a serine …
Parkinson's disease patients. Since a common mutation that replaces Gly2019 with a serine …
Cellular processes associated with LRRK 2 function and dysfunction
Mutations in the leucine‐rich repeat kinase 2 (LRRK 2)‐encoding gene are the most
common cause of monogenic Parkinson's disease. The identification of LRRK 2 …
common cause of monogenic Parkinson's disease. The identification of LRRK 2 …
Membrane localization of LRRK2 is associated with increased formation of the highly active LRRK2 dimer and changes in its phosphorylation
Z Berger, KA Smith, MJ LaVoie - Biochemistry, 2010 - ACS Publications
Autosomal dominant mutations in leucine rich repeat kinase 2 (LRRK2) are the most
common genetic cause of Parkinson's disease (PD). Despite the presence of multiple …
common genetic cause of Parkinson's disease (PD). Despite the presence of multiple …
The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway
JM Bravo-San Pedro, M Niso-Santano… - Cellular and Molecular …, 2013 - Springer
Mutations in leucine-rich repeat kinase 2 (LRRK2) are a major cause of familial
Parkinsonism, and the G2019S mutation of LRRK2 is one of the most prevalent mutations …
Parkinsonism, and the G2019S mutation of LRRK2 is one of the most prevalent mutations …
A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation
BMH Law, VA Spain, VHL Leinster, R Chia… - Journal of Biological …, 2014 - ASBMB
Mutations in LRRK2, encoding the multifunctional protein leucine-rich repeat kinase 2
(LRRK2), are a common cause of Parkinson disease. LRRK2 has been suggested to …
(LRRK2), are a common cause of Parkinson disease. LRRK2 has been suggested to …
GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2
Mutations in the LRRK2 gene cause autosomal dominant Parkinson's disease. LRRK2
encodes a multi-domain protein containing a Ras-of-complex (Roc) GTPase domain, a C …
encodes a multi-domain protein containing a Ras-of-complex (Roc) GTPase domain, a C …
LRRK2: cause, risk, and mechanism
In 2004 it was first shown that mutations in LRRK2 can cause Parkinson's disease. This
initial discovery was quickly followed by the observation that a single particular mutation is a …
initial discovery was quickly followed by the observation that a single particular mutation is a …