Cell adhesion to the extracellular matrix is fundamental to tissue integrity and human health.
Integrins are the main cellular adhesion receptors that through multifaceted roles as …

Cell adhesion to the extracellular matrix is fundamental to metazoan multicellularity and is
accomplished primarily through the integrin family of cell-surface receptors. Integrins are …

Integrins are a family of transmembrane cell surface molecules that constitute the principal
adhesion receptors for the extracellular matrix (ECM) and are indispensable for the …

Integrins are a family of heterodimeric receptors that bind to components of the extracellular
matrix and influence cellular processes as varied as proliferation and migration. These …

Integrins belong to a large family of αβ heterodimeric transmembrane proteins first
recognized as adhesion molecules that bind to dedicated elements of the extracellular …

Receptor tyrosine kinases (RTKs) and integrins cooperate to stimulate cell migration and
tumour metastasis. Here we report that an integrin influences signalling of an RTK, c-Met …

Epithelial cells adhere to a specialized extracellular matrix called the basement membrane
which allows them to polarize and form epithelial tissues. The extracellular matrix provides …

Simple Summary Pancreatic cancer (PC) is a highly aggressive malignant tumor with an
extremely poor prognosis. Early diagnosis and treatment are key to improving the survival …

Integrins contribute to cancer progression and aggressiveness by activating intracellular
signal transduction pathways and transducing mechanical tension forces. Remarkably …

Entosis is a form of epithelial cell engulfment and cannibalism prevalent in human cancer.
Until recently, the only known trigger for entosis was loss of attachment to the extracellular …