T-cell acute lymphoblastic leukemia: a roadmap to targeted therapies
V Cordo', JCG van der Zwet, K Canté-Barrett… - Blood cancer …, 2021 - aacrjournals.org
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy
characterized by aberrant proliferation of immature thymocytes. Despite an overall survival …
characterized by aberrant proliferation of immature thymocytes. Despite an overall survival …
Affinity-optimizing enhancer variants disrupt development
Enhancers control the location and timing of gene expression and contain the majority of
variants associated with disease,–. The ZRS is arguably the most well-studied vertebrate …
variants associated with disease,–. The ZRS is arguably the most well-studied vertebrate …
A multiomic atlas identifies a treatment-resistant, bone marrow progenitor-like cell population in T cell acute lymphoblastic leukemia
Refractoriness to initial chemotherapy and relapse after remission are the main obstacles to
curing T cell acute lymphoblastic leukemia (T-ALL). While tumor heterogeneity has been …
curing T cell acute lymphoblastic leukemia (T-ALL). While tumor heterogeneity has been …
E protein transcription factors as suppressors of T lymphocyte acute lymphoblastic leukemia
G Parriott, BL Kee - Frontiers in Immunology, 2022 - frontiersin.org
T Lymphocyte Acute Lymphoblastic Leukemia (ALL) is an aggressive disease arising from
transformation of T lymphocytes during their development. The mutation spectrum of T-ALL …
transformation of T lymphocytes during their development. The mutation spectrum of T-ALL …
[HTML][HTML] Mechanoresponsive ETS1 causes endothelial dysfunction and arterialization in varicose veins via NOTCH4/DLL4 signaling
Varicose veins are the most common venous disorder in humans and are characterized by
hemodynamic instability due to valvular insufficiency and orthostatic lifestyle factors. It is …
hemodynamic instability due to valvular insufficiency and orthostatic lifestyle factors. It is …
Hyperthermia promotes degradation of the acute promyelocytic leukemia driver oncoprotein ZBTB16/RARα
Q Wang, L Hussain, P Yu, C Yang, C Zhu… - Acta Pharmacologica …, 2023 - nature.com
The acute promyelocytic leukemia (APL) driver ZBTB16/RARα is generated by the t (11;
17)(q23; q21) chromosomal translocation, which is resistant to combined treatment of all …
17)(q23; q21) chromosomal translocation, which is resistant to combined treatment of all …
Cdc73 protects Notch-induced T-cell leukemia cells from DNA damage and mitochondrial stress
AF Melnick, C Mullin, K Lin, AC McCarter, S Liang… - Blood, 2023 - ashpublications.org
Activated Notch signaling is highly prevalent in T-cell acute lymphoblastic leukemia (T-ALL),
but pan-Notch inhibitors showed excessive toxicity in clinical trials. To find alternative ways …
but pan-Notch inhibitors showed excessive toxicity in clinical trials. To find alternative ways …
ETS1 function in leukemia and lymphoma
RA Luchtel - Transcription factors in blood cell development, 2024 - Springer
Abstract ETS proto-oncogene 1 (ETS1) is a transcription factor (TF) critically involved in
lymphoid cell development and function. ETS1 expression is tightly regulated throughout …
lymphoid cell development and function. ETS1 expression is tightly regulated throughout …
Stroke-associated intergenic variants modulate a human FOXF2 transcriptional enhancer
SNPs associated with human stroke risk have been identified in the intergenic region
between Forkhead family transcription factors FOXF2 and FOXQ1, but we lack a mechanism …
between Forkhead family transcription factors FOXF2 and FOXQ1, but we lack a mechanism …
ETS1 is a novel transcriptional regulator of adult T-cell leukemia/lymphoma of North American descent
Adult T-cell leukemia/lymphoma (ATLL) is an aggressive T-cell lymphoma associated with
the human T-cell lymphotropic virus type 1 virus endemic in regions including Japan, the …
the human T-cell lymphotropic virus type 1 virus endemic in regions including Japan, the …