Histone modifying enzymes play critical roles in many key cellular processes and are
appealing proteins for targeting by small molecules in disease. However, while the functions …

Currently, nine polyglutamine (polyQ) expansion diseases are known. They include
spinocerebellar ataxias (SCA1, 2, 3, 6, 7, 17), spinal and bulbar muscular atrophy (SBMA) …

Compelling evidence indicates that in Huntington's disease (HD), mutation of huntingtin
(HTT) alters several aspects of early brain development such as synaptogenesis. It is not …

The cytoskeleton plays important roles in many essential processes at the cellular and
organismal levels, including cell migration and motility, cell division, and the establishment …

Development is a complex process that occurs throughout the life cycle. F-actin, a major
component of the cytoskeleton, is essential for the morphogenesis of tissues and organs …

Epigenetic regulation plays an important role in the occurrence, development and treatment
of tumors. The histone methyltransferase SET-domain-containing 2 (SETD2) plays a key role …

Brain size is controlled by several factors during neuronal development, including neural
progenitor proliferation, neuronal arborization, gliogenesis, cell death, and synaptogenesis …

Understanding the mechanisms that drive HIV expression and latency is a key goal for
achieving an HIV cure. Here we investigate the role of the SETD2 histone methyltransferase …

The covalent modification of histones is critical for many biological functions in mammals,
including gene regulation and chromatin structure. Posttranslational histone modifications …

The cytoskeleton comprises networks of different biopolymers, which serve various cellular
functions. To accomplish these tasks, their mechanical properties are of particular …