Molecular oxygen (O2) sustains intracellular bioenergetics and is consumed by numerous
biochemical reactions, making it essential for most species on Earth. Accordingly, decreased …

Hypoxia is an inherent pathophysiological characteristic of chronic kidney disease (CKD),
which is closely associated with the development of renal inflammation and fibrosis, as well …

Increasing evidence indicates that reactive oxygen species (ROS), consisting of superoxide,
hydrogen peroxide, and multiple others, do not only cause oxidative stress, but rather may …

Vascular endothelial growth factor (VEGF) is a highly specific mitogen for vascular
endothelial cells. Five VEGF isoforms are generated as a result of alternative splicing from a …

The regulation of angiogenesis by hypoxia is an important component of homeostatic
mechanisms that link vascular oxygen supply to metabolic demand. Molecular …

Cells respond to stress stimuli through coordinated changes in gene expression. The
regulation of translation is often used under these circumstances because it allows …

The association of pericytes (PCs) to newly formed blood vessels has been suggested to
regulate endothelial cell (EC) proliferation, survival, migration, differentiation, and vascular …

Hypoxia occurs in the majority of tumours, promoting angiogenesis, metastasis and
resistance to therapy. Responses to hypoxia are orchestrated in part through activation of …

Vascular endothelial growth factor (VEGF) is a secreted mitogen highly specific for cultured
endothelial cells. In vivo VEGF induces microvascular permeability and plays a central role …

Hypoxia stimulates angiogenesis through the binding of hypoxia-inducible factors to the
hypoxia-response element in the vascular endothelial growth factor (Vegf) promotor. Here …