Hematopoietic stem cells (HSCs) support haematopoiesis throughout life and give rise to the
whole variety of cells of the immune system. Develo** in the early embryo, passing …

Single-cell analysis in living humans is essential for understanding disease mechanisms,
but it is impractical in non-regenerative organs, such as the eye and brain, because tissue …

To define metrics of phenotypic aging, it is essential to identify biological and environmental
factors that influence the pace of aging. Previous attempts to develop aging metrics were …

Human aging is characterized by a gradual decline in physiological functions and an
increased susceptibility to various diseases. The complex mechanisms underlying human …

In this review, we describe evidence that supports building a metaverse to promote healthy
longevity. We propose that the metaverse offers several physical advantages (architecture …

Measuring the abundance of biological molecules and their chemical modifications in blood
and tissues has been the cornerstone of research and medical diagnoses for decades …

The risk of develo** chronic illnesses and disabilities is increasing with age. To predict
and prevent aging, biomarkers relevant to the aging process must be identified. This paper …

The study of age‐related biomarkers from different biofluids and tissues within the same
individual might provide a more comprehensive understanding of age‐related changes …

Background The IGF-1 signaling pathway has been deeply involved in the aging
mechanism. The insulin-like growth factor binding protein 3 (IGFBP-3) is a protein that binds …

Since ancient times aging has also been regarded as a disease, and humankind has always
strived to extend the natural lifespan. Analyzing the genes involved in aging and disease …