Hydrogenation is one of the most fundamental transformations in organic synthesis, and its
industrial applications span from fine chemicals to pharmaceuticals synthesis. 1− 3 Direct …

The activation of a substrate by a chiral catalyst is now regarded as one of the most powerful
strategies that can be employed in the art of asymmetric synthesis. 1 The development of …

The asymmetric hydrogenation of heteroarenes has recently emerged as an effective
strategy for the direct access to enantioenriched, saturated heterocycles. Although several …

The development of chiral catalysts that can provide high enantioselectivities across a wide
assortment of substrates or reaction range is a priority for many catalyst design efforts. While …

Sterically encumbered Lewis acid and Lewis base combinations do not undergo the
ubiquitous neutralization reaction to form “classical” Lewis acid/Lewis base adducts. Rather …

In recent years, Hantzsch esters and their related organic hydride donors have been widely
utilized in biomimetic approaches of asymmetric transfer hydrogenation (ATH) reactions …

Enantioselective synthesis with small-molecule chiral hydrogen-bond donors has emerged
as a frontier of research in the field of asymmetric catalysis. Organic chemists have …

The review examines the chiral amine literature from 2000–2009 (May) concerning
enantioselective and diastereoselective methods for N‐acylenamide and enamine …

The fundamental role of the Lewis-acid catalyst lies in the activation of the CdX bond (X) O,
NR, CR2), thereby decreasing the LUMO energy and promoting nucleophilic addition to the …

Chiral phosphoric acids derived from axially chiral biaryls and related chiral Brønsted acids
have emerged as an attractive and widely applicable class of enantioselective …