Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …

Introduction Biphasic release, as a special drug-modified release profile that combines
immediate and sustained release, allows fast therapeutic action and retains blood drug …

A healthy brain is protected by the blood–brain barrier (BBB), which is formed by the
endothelial cells that line brain capillaries. The BBB plays an extremely important role in …

Abstract Baicalin (BA), a multi-target neuroprotective agent, has poor solubility resulting in
low bioavailability. In this study, multidrug-loaded liposomes were prepared by …

Oxidative stress (OS) and neuroinflammation are critical pathological processes in
secondary brain injury (SBI) after intracerebral hemorrhage (ICH), and their intimate …

Numerous hemorrhagic disorders, particularly those presenting deep hemorrhage, pose
diagnostic challenges, often leading to delayed treatment and severe outcomes. Near …

Ischemic stroke causes acute CNS injury and long-term disability, with limited treatment
options such as surgical clot removal or clot-busting drugs. Neuroprotective therapies are …

Blood-brain barrier (BBB) dysfunction plays a pivotal role in the pathology of chronic
cerebral hypoperfusion (CCH)-related neurodegenerative diseases. Continuous endothelial …

Background The therapeutic strategies for acute ischemic stroke were faced with substantial
constraints, emphasizing the necessity to safeguard neuronal cells during cerebral ischemia …

Stroke is a leading cause of global mortality and severe disability. However, current
strategies used for treating ischemic stroke lack specific targeting capabilities, exhibit poor …