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Stem cells and liver regeneration
One of the defining features of the liver is the capacity to maintain a constant size despite
injury. Although the precise molecular signals involved in the maintenance of liver size are …
injury. Although the precise molecular signals involved in the maintenance of liver size are …
Intrahepatic cholangiocarcinoma: current perspectives
Intrahepatic cholangiocarcinoma (ICC) is the second most common malignancy arising from
the liver. ICC makes up about 10% of all cholangiocarcinomas. It arises from the peripheral …
the liver. ICC makes up about 10% of all cholangiocarcinomas. It arises from the peripheral …
A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells
The variability in the prognosis of individuals with hepatocellular carcinoma (HCC) suggests
that HCC may comprise several distinct biological phenotypes. These phenotypes may …
that HCC may comprise several distinct biological phenotypes. These phenotypes may …
Intratumor heterogeneity in hepatocellular carcinoma
Purpose: Morphologic intratumor heterogeneity is well known to exist in hepatocellular
carcinoma (HCC), but very few systematic analyses of this phenomenon have been …
carcinoma (HCC), but very few systematic analyses of this phenomenon have been …
The clinicopathological and prognostic relevance of cytokeratin 7 and 19 expression in hepatocellular carcinoma. A possible progenitor cell origin
Aims: Cytokeratin (CK) 7 and CK19 expression, present in hepatic progenitor cells (HPCs)
and in cholangiocytes but not in normal hepatocytes, has been reported in some …
and in cholangiocytes but not in normal hepatocytes, has been reported in some …
Clinicopathological study on cholangiolocellular carcinoma suggesting hepatic progenitor cell origin
Cholangiolocellular carcinoma (CLC), a subtype of cholangiocellular carcinoma (CC), is
thought to originate from the ductules/canals of Hering, where hepatic progenitor cells …
thought to originate from the ductules/canals of Hering, where hepatic progenitor cells …
CK19-positive hepatocellular carcinoma is a characteristic subtype
The heterogeneity of hepatocellular carcinoma (HCC) commonly leads to therapeutic failure
of HCC. Cytokeratin 19 (CK19) is well acknowledged as a biliary/progenitor cell marker and …
of HCC. Cytokeratin 19 (CK19) is well acknowledged as a biliary/progenitor cell marker and …
Combined hepatocellular cholangiocarcinoma (cHCC-CC): an update of genetics, molecular biology, and therapeutic interventions
Combined hepatocellular cholangiocarcinoma (CC) is a rare and aggressive primary
hepatic malignancy with significant histological and biological heterogeneity. It presents with …
hepatic malignancy with significant histological and biological heterogeneity. It presents with …
Entry of hepatitis B virus into immortalized human primary hepatocytes by clathrin-dependent endocytosis
The lack of a suitable in vitro hepatitis B virus (HBV) infectivity model has limited
examination of the early stages of the virus-cell interaction. In this study, we used an …
examination of the early stages of the virus-cell interaction. In this study, we used an …
Cytokeratin 19 expression in hepatocellular carcinoma predicts early postoperative recurrence
T Uenishi, S Kubo, T Yamamoto, T Shuto… - Cancer …, 2003 - Wiley Online Library
Clinicopathologic features and postoperative outcomes were investigated for patients who
underwent curative surgery for biliary marker (CK7 and CK19)‐positive hepatocellular …
underwent curative surgery for biliary marker (CK7 and CK19)‐positive hepatocellular …