Epidemiological studies have shown a clear association between maternal infection and
schizophrenia or autism in the progeny. Animal models have revealed maternal immune …

A substantial and diverse body of literature suggests that the pathophysiology of
schizophrenia is related to deficits of bioenergetic function. While antipsychotics are an …

Background Mitochondrial dysfunction and defects in oxidative metabolism are a
characteristic feature of many chronic illnesses not currently classified as mitochondrial …

Mitochondria play a critical role in regulating cellular functions including bioenergetics,
calcium homeostasis, redox signalling, and apoptotic cell death. Mitochondria are also …

Schizophrenia and bipolar disorder are disabling psychiatric disorders with a worldwide
prevalence of approximately 1%. Both disorders present chronic and deteriorating …

Psychiatric disorders represent a great medical and social challenge and people suffering
from these conditions face many impairments regarding personal and professional life. In …

Epidemiological, genetic, transcriptome, postmortem, peripheral biomarker, and therapeutic
studies of schizophrenia all point to a dysregulation of both innate and adaptive immune …

Major depressive disorder (MDD) is a leading cause of disability worldwide and results
tragically in the loss of almost one million lives in Western societies every year. This is due to …

Alterations in glutamate, the primary excitatory neurotransmitter in the brain, are implicated
in several psychiatric diseases. Many of these psychiatric diseases display epidemiological …

Recent advancements in mass spectrometry (MS) have revolutionized quantitative
proteomics, with multiplex isotope labeling emerging as a key strategy for enhancing …