[HTML][HTML] The neutrophil

GL Burn, A Foti, G Marsman, DF Patel, A Zychlinsky - Immunity, 2021 - cell.com
Neutrophils are immune cells with unusual biological features that furnish potent
antimicrobial properties. These cells phagocytose and subsequently kill prokaryotic and …

Neutrophils as emerging therapeutic targets

T Németh, M Sperandio, A Mócsai - Nature reviews Drug discovery, 2020 - nature.com
Neutrophils are the most abundant circulating leukocytes, being the first line of defence
against bacterial and fungal infections. However, neutrophils also contribute to tissue …

Neutrophils and NETs in modulating acute and chronic inflammation

FVS Castanheira, P Kubes - … Journal of the American Society of …, 2019 - ashpublications.org
Neutrophils are an absolutely essential part of the innate immune system, playing an
essential role in the control of infectious diseases but more recently are also being viewed …

The cytokines of asthma

BN Lambrecht, H Hammad, JV Fahy - Immunity, 2019 - cell.com
Asthma is a chronic inflammatory airway disease associated with type 2 cytokines
interleukin-4 (IL-4), IL-5, and IL-13, which promote airway eosinophilia, mucus …

NETosis proceeds by cytoskeleton and endomembrane disassembly and PAD4-mediated chromatin decondensation and nuclear envelope rupture

HR Thiam, SL Wong, R Qiu, M Kittisopikul… - Proceedings of the …, 2020 - pnas.org
Neutrophil extracellular traps (NETs) are web-like DNA structures decorated with histones
and cytotoxic proteins that are released by activated neutrophils to trap and neutralize …

[HTML][HTML] Neutrophils in respiratory viral infections

C Johansson, FCM Kirsebom - Mucosal immunology, 2021 - Elsevier
Viral respiratory infections are a common cause of severe disease, especially in infants,
people who are immunocompromised, and in the elderly. Neutrophils, an important innate …

Extracellular DNA, neutrophil extracellular traps, and inflammasome activation in severe asthma

ME Lachowicz-Scroggins, EM Dunican… - American journal of …, 2019 - atsjournals.org
Rationale: Extracellular DNA (eDNA) and neutrophil extracellular traps (NETs) are
implicated in multiple inflammatory diseases. NETs mediate inflammasome activation and IL …

Phagocytosis, degranulation and extracellular traps release by neutrophils—the current knowledge, pharmacological modulation and future prospects

B Gierlikowska, A Stachura, W Gierlikowski… - Frontiers in …, 2021 - frontiersin.org
Neutrophils are crucial elements of innate immune system, which assure host defense via a
range of effector functions, such as phagocytosis, degranulation, and NET formation. The …

The role of neutrophils in host defense and disease

HK Lehman, BH Segal - Journal of Allergy and Clinical Immunology, 2020 - Elsevier
Neutrophils, the most abundant circulating leukocyte, are critical for host defense.
Granulopoiesis is under the control of transcriptional factors and culminates in mature …

[HTML][HTML] Treatment options in type-2 low asthma

TSC Hinks, SJ Levine… - European Respiratory …, 2021 - publications.ersnet.org
Monoclonal antibodies targeting IgE or the type-2 cytokines interleukin (IL)-4, IL-5 and IL-13
are proving highly effective in reducing exacerbations and symptoms in people with severe …