On the expanding roles of tRNA fragments in modulating cell behavior

R Magee, I Rigoutsos - Nucleic acids research, 2020 - academic.oup.com
The fragments that derive from transfer RNAs (tRNAs) are an emerging category of
regulatory RNAs. Known as tRFs, these fragments were reported for the first time only a …

tRNA-derived fragments: Mechanisms underlying their regulation of gene expression and potential applications as therapeutic targets in cancers and virus infections

X Yu, Y **e, S Zhang, X Song, B **ao, Z Yan - Theranostics, 2021 - pmc.ncbi.nlm.nih.gov
tRNA-derived fragments (tRFs) are a new category of regulatory noncoding RNAs with
distinct biological functions in cancers and stress-induced diseases. Herein, we first …

Exosomes in human semen carry a distinctive repertoire of small non-coding RNAs with potential regulatory functions

L Vojtech, S Woo, S Hughes, C Levy… - Nucleic acids …, 2014 - academic.oup.com
Semen contains relatively ill-defined regulatory components that likely aid fertilization, but
which could also interfere with defense against infection. Each ejaculate contains trillions of …

tRNA-derived small RNAs target transposable element transcripts

G Martinez, SG Choudury, RK Slotkin - Nucleic acids research, 2017 - academic.oup.com
Abstract tRNA-derived RNA fragments (tRFs) are 18–26 nucleotide small RNAs that are not
random degradation products, but are rather specifically cleaved from mature tRNA …

tRNA-derived fragments (tRFs): emerging new roles for an ancient RNA in the regulation of gene expression

SP Keam, G Hutvagner - Life, 2015 - mdpi.com
This review will summarise the recent discoveries and current state of research on short
noncoding RNAs derived from tRNAs—known as tRNA-derived fragments (tRFs). It will …

MINTbase v2. 0: a comprehensive database for tRNA-derived fragments that includes nuclear and mitochondrial fragments from all The Cancer Genome Atlas projects

V Pliatsika, P Loher, R Magee, AG Telonis… - Nucleic acids …, 2018 - academic.oup.com
MINTbase is a repository that comprises nuclear and mitochondrial tRNA-derived fragments
('tRFs') found in multiple human tissues. The original version of MINTbase comprised tRFs …

Slicing tRNAs to boost functional ncRNA diversity

J Gebetsberger, N Polacek - RNA biology, 2013 - Taylor & Francis
Post-transcriptional cleavage of RNA molecules to generate smaller fragments is a
widespread mechanism that enlarges the structural and functional complexity of cellular …

Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes

C Cosentino, S Toivonen, E Diaz Villamil… - Nucleic acids …, 2018 - academic.oup.com
Transfer RNAs (tRNAs) are non-coding RNA molecules essential for protein synthesis. Post-
transcriptionally they are heavily modified to improve their function, folding and stability …

Drosophila tsRNAs preferentially suppress general translation machinery via antisense pairing and participate in cellular starvation response

S Luo, F He, J Luo, S Dou, Y Wang… - Nucleic acids …, 2018 - academic.oup.com
Transfer RNA-derived small RNAs (tsRNAs) are an emerging class of small RNAs, yet their
regulatory roles have not been well understood. Here we studied the molecular mechanisms …

tRNA-derived small RNAs: biogenesis, modification, function and potential impact on human disease development

V Oberbauer, MR Schaefer - Genes, 2018 - mdpi.com
Transfer RNAs (tRNAs) are abundant small non-coding RNAs that are crucially important for
decoding genetic information. Besides fulfilling canonical roles as adaptor molecules during …