The corticotropin-releasing hormone cells in the paraventricular nucleus of the
hypothalamus (CRH PVN) control the slow endocrine response to stress. The synapses on …

Sodium (Na+) is crucial for numerous homeostatic processes in the body and,
consequentially, its levels are tightly regulated by multiple organ systems. Sodium is …

Over-activation of the brain renin-angiotensin system (RAS) has been implicated in the
etiology of anxiety disorders. Angiotensin converting enzyme 2 (ACE2) inhibits RAS activity …

Adolescence is a period of substantial neuroplasticity in stress regulatory neurocircuits.
Chronic stress exposure during this period leads to long-lasting changes in neuroendocrine …

Oxytocin (OT) is a neuropeptide that exerts multiple actions throughout the brain and
periphery. Within the brain, OT regulates diverse neural populations, including neural …

Aldosterone and mineralocorticoid receptor (MR)-function have been related to depression.
We examined central and peripheral parameters of MR-function in order to characterize their …

Significant prior evidence indicates that centrally acting oxytocin robustly modulates stress
responsiveness and anxiety‐like behaviour, although the neural mechanisms behind these …

Studies indicate that adolescent exposure to stress is a potent environmental factor that
contributes to psychological and physiological disorders, though the mechanisms that …

Previous investigation by our laboratory found that acute hypernatremia potentiates an
oxytocinergic tone that inhibits parvocellular neurosecretory neurons in the paraventricular …

Oxytocin (OT) has gained considerable interest in recent years as a potential treatment for
alcoholism and other substance use disorders. Evidence continues to mount that OT …