Food allergy

H Renz, KJ Allen, SH Sicherer, HA Sampson… - Nature reviews Disease …, 2018 - nature.com
Food allergies manifest in a variety of clinical conditions within the gastrointestinal tract, skin
and lungs, with the most dramatic and sometimes fatal manifestation being anaphylactic …

Pathophysiology of eosinophilic esophagitis

KM O'Shea, SS Aceves, ES Dellon, SK Gupta… - Gastroenterology, 2018 - Elsevier
Eosinophilic esophagitis is an emerging disease that is distinguished from
gastroesophageal reflux disease by the expression of a unique esophageal transcriptome …

A human model of asthma exacerbation reveals transcriptional programs and cell circuits specific to allergic asthma

J Alladina, NP Smith, T Kooistra, K Slowikowski… - Science …, 2023 - science.org
Asthma is a chronic disease most commonly associated with allergy and type 2
inflammation. However, the mechanisms that link airway inflammation to the structural …

Eosinophil knockout humans: uncovering the role of eosinophils through eosinophil-directed biological therapies

EA Jacobsen, DJ Jackson, E Heffler… - Annual review of …, 2021 - annualreviews.org
The enigmatic eosinophil has emerged as an exciting component of the immune system,
involved in a plethora of homeostatic and inflammatory responses. Substantial progress has …

DNA methylation in nasal epithelium, atopy, and atopic asthma in children: a genome-wide study

E Forno, T Wang, C Qi, Q Yan, CJ Xu… - The lancet Respiratory …, 2019 - thelancet.com
Background Epigenetic mechanisms could alter the airway epithelial barrier and ultimately
lead to atopic diseases such as asthma. We aimed to identify DNA methylation profiles that …

Pathophysiology of non-IgE-mediated food allergy

S Zhang, S Sicherer, MC Berin… - ImmunoTargets and …, 2021 - Taylor & Francis
Non-IgE-mediated food allergies are a group of disorders characterized by subacute or
chronic inflammatory processes in the gut. Unlike IgE mediated food allergies that may result …

Butyrate and propionate restore interleukin 13‐compromised esophageal epithelial barrier function

MTA Kleuskens, ML Haasnoot, BM Herpers… - Allergy, 2022 - Wiley Online Library
Abstract Background Eosinophilic esophagitis (EoE) is a food allergen driven disease that is
accompanied by interleukin (IL) 13 overexpression and esophageal barrier dysfunction …

Eosinophilic esophagitis: clinical, endoscopic, histologic and therapeutic differences and similarities between children and adults

P Visaggi, E Savarino, G Sciume… - Therapeutic …, 2021 - journals.sagepub.com
In the absence of secondary causes, eosinophilic esophagitis (EoE) is a chronic, local,
progressive, T-helper type 2 immune-mediated disorder characterized by symptoms of …

Breaking down the complex pathophysiology of eosinophilic esophagitis

B Underwood, TD Troutman, JT Schwartz - Annals of Allergy, Asthma & …, 2023 - Elsevier
Eosinophilic esophagitis (EoE) is a chronic and progressive immune-mediated disease of
the esophagus associated with antigen-driven type 2 inflammation and symptoms of …

[HTML][HTML] Pediatric eosinophilic esophagitis: a review for the clinician

S Barni, S Arasi, C Mastrorilli, L Pecoraro… - Italian Journal of …, 2021 - Springer
Eosinophilic esophagitis (EoE) is a chronic clinical-pathologic disease characterized by
eosinophilic infiltration of the esophageal epithelium with esophageal dysfunction …