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Signal pathways of melanoma and targeted therapy
W Guo, H Wang, C Li - Signal transduction and targeted therapy, 2021 - nature.com
Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …
[HTML][HTML] BRAF inhibitors: molecular targeting and immunomodulatory actions
I Proietti, N Skroza, S Michelini, A Mambrin, V Balduzzi… - Cancers, 2020 - mdpi.com
The BRAF inhibitors vemurafenib, dabrafenib and encorafenib are used in the treatment of
patients with BRAF-mutant melanoma. They selectively target BRAF kinase and thus …
patients with BRAF-mutant melanoma. They selectively target BRAF kinase and thus …
BCG turns 100: its nontraditional uses against viruses, cancer, and immunologic diseases
First administered to a human subject as a tuberculosis (TB) vaccine on July 18, 1921,
Bacillus Calmette-Guérin (BCG) has a long history of use for the prevention of TB and later …
Bacillus Calmette-Guérin (BCG) has a long history of use for the prevention of TB and later …
Melanoma classification and management in the era of molecular medicine
Cutaneous melanoma (CM) encompasses a group of pigmented tumors that arise from skin
melanocytes. Melanocytes are neural crest-derived cells that commonly migrate to the skin …
melanocytes. Melanocytes are neural crest-derived cells that commonly migrate to the skin …
Long non-coding RNAs (lncRNAs); roles in tumorigenesis and potentials as biomarkers in cancer diagnosis
New research has indicated that long non-coding RNAs (lncRNAs) play critical roles in a
broad range of biological processes, including the pathogenesis of many complex human …
broad range of biological processes, including the pathogenesis of many complex human …
Chemotherapy in cutaneous melanoma: is there still a role?
Abstract Purpose of Review In the preceding decade, the management of metastatic
cutaneous melanoma has been revolutionised with the development of highly effective …
cutaneous melanoma has been revolutionised with the development of highly effective …
[HTML][HTML] Systemic therapy of metastatic melanoma: on the road to cure
J Steininger, FF Gellrich, A Schulz, D Westphal… - Cancers, 2021 - mdpi.com
Simple Summary Malignant melanoma is more dangerous than most other skin cancers due
to its ability to spread early and aggressively. Until the development of new therapeutic …
to its ability to spread early and aggressively. Until the development of new therapeutic …
The value of 18F-FDG PET/CT for predicting or monitoring immunotherapy response in patients with metastatic melanoma: a systematic review and meta-analysis
Purpose To investigate the ability of 18 F-FDG PET/CT to assess the response of patients
with metastatic melanoma to immunotherapy. Methods A comprehensive search of the …
with metastatic melanoma to immunotherapy. Methods A comprehensive search of the …
Immune checkpoint inhibitors to treat cutaneous malignancies
DM Barrios, MH Do, GS Phillips, MA Postow… - Journal of the American …, 2020 - Elsevier
As the incidence of cutaneous malignancies continues to rise and their treatment with
immunotherapy expands, dermatologists and their patients are more likely to encounter …
immunotherapy expands, dermatologists and their patients are more likely to encounter …
Assessing the prognostic significance of tumor-infiltrating lymphocytes in patients with melanoma using pathologic features identified by natural language processing
Importance Although tumor-infiltrating lymphocytes (TILs) are an important histopathologic
characteristic reflecting host immune response in patients with melanoma, their prognostic …
characteristic reflecting host immune response in patients with melanoma, their prognostic …