This Review explores the class of plant-derived macrocyclic peptides called cyclotides. We
include an account of their discovery, characterization, and distribution in the plant kingdom …

Natural polypeptides, a kind of molecular polymer with obvious biological activity, are widely
existing in nature. They participate in various physiological activities of living organisms and …

The cyclic peptides, cyclotides, are identified mostly with 29–31-aa (amino acid residues)
but rarely with≥ 34-aa in plants. Viola philippica is a well-known medicinal plant but a rare …

Cyclotides are an emerging class of disulfide-rich plant cyclic peptides, believed to be
present in plants for defence purposes. Their exceptional thermal, chemical and enzymatic …

About 3000 tons of beans are not used in human food due to hardening. Several studies on
bean-derived bioactive peptides have shown potential to treat some diseases, including …

Cyclotides are cysteine-rich plant-derived peptides composed of 28–37 amino acids with a
head-to-tail cyclic backbone and a knotted arrangement of three conserved disulfide bonds …

Background: Gac (Momordica cochinchinensis Spreng) seeds have long been used in
traditional medicine as a remedy for numerous conditions due to a range of bioactive …

Gac (Momordica cochinchinensis Spreng.) seeds contain bioactive compounds with
medicinal properties. This study aimed to determine a suitable solvent and extraction …

We optimized a peptide extraction and LC–MS protocol for identification and quantification
of antimicrobial peptides (AMPs) in biological samples. Amphipathic AMPs were extracted …

Cyclic proteins have evolved for millions of years across all kingdoms of life to confer
structural stability over their acyclic counterparts while maintaining intrinsic functional …