The physiological functions of human peroxisomes
RJA Wanders, M Baes, D Ribeiro… - Physiological …, 2023 - journals.physiology.org
Peroxisomes are subcellular organelles that play a central role in human physiology by
catalyzing a range of unique metabolic functions. The importance of peroxisomes for human …
catalyzing a range of unique metabolic functions. The importance of peroxisomes for human …
Peroxisome biogenesis
PE Purdue, PB Lazarow - Annual review of cell and …, 2001 - annualreviews.org
▪ Abstract Fifteen years ago, we had a model of peroxisome biogenesis that involved growth
and division of preexisting peroxisomes. Today, thanks to genetically tractable model …
and division of preexisting peroxisomes. Today, thanks to genetically tractable model …
COVID‐19 induces neuroinflammation and suppresses peroxisomes in the brain
Objective Peroxisome injury occurs in the central nervous system (CNS) during multiple
virus infections that result in neurological disabilities. We investigated host neuroimmune …
virus infections that result in neurological disabilities. We investigated host neuroimmune …
Peroxisome biogenesis, membrane contact sites, and quality control
Peroxisomes are conserved organelles of eukaryotic cells with important roles in cellular
metabolism, human health, redox homeostasis, as well as intracellular metabolite transfer …
metabolism, human health, redox homeostasis, as well as intracellular metabolite transfer …
Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: conserved Pex5p …
H Otera, K Setoguchi, M Hamasaki… - … and cellular biology, 2002 - Taylor & Francis
Two isoforms of the peroxisomal targeting signal type 1 (PTS1) receptor, termed Pex5pS
and (37-amino-acid-longer) Pex5pL, are expressed in mammals. Pex5pL transports PTS1 …
and (37-amino-acid-longer) Pex5pL, are expressed in mammals. Pex5pL transports PTS1 …
Peroxisome biogenesis in mammalian cells
Y Fujiki, K Okumoto, S Mukai, M Honsho… - Frontiers in …, 2014 - frontiersin.org
To investigate peroxisome assembly and human peroxisome biogenesis disorders (PBDs)
such as Zellweger syndrome, thirteen different complementation groups (CGs) of Chinese …
such as Zellweger syndrome, thirteen different complementation groups (CGs) of Chinese …
The peroxisome counteracts oxidative stresses by suppressing catalase import via Pex14 phosphorylation
K Okumoto, M El Shermely, M Natsui, H Kosako… - Elife, 2020 - elifesciences.org
Most of peroxisomal matrix proteins including a hydrogen peroxide (H2O2)-decomposing
enzyme, catalase, are imported in a peroxisome-targeting signal type-1 (PTS1)-dependent …
enzyme, catalase, are imported in a peroxisome-targeting signal type-1 (PTS1)-dependent …
The membrane peroxin PEX3 induces peroxisome-ubiquitination-linked pexophagy
S Yamashita, K Abe, Y Tatemichi, Y Fujiki - Autophagy, 2014 - Taylor & Francis
Peroxisomes are degraded by a selective type of autophagy known as pexophagy. Several
different types of pexophagy have been reported in mammalian cells. However, the …
different types of pexophagy have been reported in mammalian cells. However, the …
[HTML][HTML] Protein import machineries of peroxisomes
R Rucktäschel, W Girzalsky, R Erdmann - Biochimica et Biophysica Acta …, 2011 - Elsevier
Peroxisomes are a class of structurally and functionally related organelles present in almost
all eukaryotic cells. The importance of peroxisomes for human life is highlighted by severe …
all eukaryotic cells. The importance of peroxisomes for human life is highlighted by severe …
Outer mitochondrial membrane E3 Ub ligase MARCH5 controls de novo peroxisome biogenesis
N Verhoeven, Y Oshima, E Cartier, CC Bippes… - Developmental Cell, 2025 - cell.com
We report that the outer mitochondrial membrane (OMM)-associated E3 Ub ligase MARCH5
is vital for generating mitochondria-derived pre-peroxisomes. In human immortalized cells …
is vital for generating mitochondria-derived pre-peroxisomes. In human immortalized cells …