[HTML][HTML] Stachybotrys chartarum—A Hidden Treasure: Secondary Metabolites, Bioactivities, and Biotechnological Relevance

SRM Ibrahim, H Choudhry, AH Asseri, MA Elfaky… - Journal of Fungi, 2022 - mdpi.com
Fungi are renowned as a fountainhead of bio-metabolites that could be employed for
producing novel therapeutic agents, as well as enzymes with wide biotechnological and …

[HTML][HTML] Chaetomugilins and chaetoviridins—promising natural metabolites: structures, separation, characterization, biosynthesis, bioactivities, molecular docking, and …

AM Omar, GA Mohamed, SRM Ibrahim - Journal of Fungi, 2022 - mdpi.com
Fungi are recognized as luxuriant metabolic artists that generate propitious biometabolites.
Historically, fungal metabolites have largely been investigated as leads for various …

Targeted discovery of glycosylated natural products by tailoring enzyme-guided genome mining and MS-based metabolome analysis

D Chen, Z Song, J Han, J Liu, H Liu… - Journal of the American …, 2024 - ACS Publications
Glycosides make up a biomedically important class of secondary metabolites. Most naturally
occurring glycosides were isolated from plants and bacteria; however, the chemical diversity …

Mechanism behind the programmed biosynthesis of heterotrimeric fungal depside thielavin A

Q Ji, H **ang, WG Wang, Y Matsuda - Angewandte Chemie, 2024 - Wiley Online Library
Thielavin A (1) is a fungal depside composed of one 3‐methylorsellinic acid and two 3, 5‐
dimethylorsellinic acid units. It displays diverse biological activities. However, the …

Depside bond formation by the starter-unit acyltransferase domain of a fungal polyketide synthase

L Chen, X Wei, Y Matsuda - Journal of the American Chemical …, 2022 - ACS Publications
Depsides are polyphenolic molecules comprising two or more phenolic acid derivatives
linked by an ester bond, which is called a depside bond in these molecules. Despite more …

Extracellular Vesicles from Candida haemulonii var. vulnera Modulate Macrophage Oxidative Burst

BTM Oliveira, TMH Dourado, PWS Santos… - Journal of Fungi, 2023 - mdpi.com
Members of the Candida haemulonii species complex are multidrug-resistant emergent
yeast pathogens able to cause superficial and invasive infections in risk populations. Fungal …

Docking and molecular dynamic investigations of phenylspirodrimanes as cannabinoid receptor-2 agonists

AM Omar, AS Aljahdali, MK Safo, GA Mohamed… - Molecules, 2022 - mdpi.com
Cannabinoid receptor ligands are renowned as being therapeutically crucial for treating
diverse health disorders. Phenylspirodrimanes are meroterpenoids with unique and varied …

Didepside Formation by the Nonreducing Polyketide Synthase Preu6 of Preussia isomera Requires Interaction of Starter Acyl Transferase and Thioesterase Domains

Q Liu, D Zhang, S Gao, X Cai, M Yao… - Angewandte Chemie …, 2023 - Wiley Online Library
Orsellinic acid (OA) derivatives are produced by filamentous fungi using nonreducing
polyketide synthases (nrPKSs). The chain‐releasing thioesterase (TE) domains of such …

Metabologenomics-Inspired Discovery and Combinatorial Biosynthesis-Based Diversification of Fungal O-Glycosylated Depsides

H Yang, Z Shang, Y Chen, F Li, K Li, H Zhu… - Organic …, 2024 - ACS Publications
Through metabologenomics mining, we prioritized Exophiala xenobiotica SDU 039, a deep-
sea sediment-derived fungus producing O-glycosylated depsides (1–9), including seven …

[HTML][HTML] Aspergillus ochraceus: Metabolites, Bioactivities, Biosynthesis, and Biotechnological Potential

RH Hareeri, MM Aldurdunji, HM Abdallah, AA Alqarni… - Molecules, 2022 - mdpi.com
Fungus continues to attract great attention as a promising pool of biometabolites. Aspergillus
ochraceus Wilh (Aspergillaceae) has established its capacity to biosynthesize a myriad of …