Influenza virus infections pose a significant threat to public health due to annual seasonal
epidemics and occasional pandemics. Influenza is also associated with significant economic …

The influenza A virus was isolated for the first time in 1931, and the first attempts to develop
a vaccine against the virus began soon afterwards. In addition to causing seasonal …

The successful isolation of a human influenza virus in 1933 was soon followed by the first
attempts to develop an influenza vaccine. Nowadays, vaccination is still the most effective …

Influenza vaccines used today are strain specific and need to be adapted every year to try
and match the antigenicity of the virus strains that are predicted to cause the next epidemic …

Introduction: Current influenza vaccines can prevent disease caused by influenza viruses
but require annual administration and almost yearly reformulation. An attractive alternative …

Respiratory viruses infections caused by influenza viruses, human parainfluenza virus
(hPIV), respiratory syncytial virus (RSV) and coronaviruses are an eminent threat for public …

Vaccines and vaccination have emerged during the past two decades as essential tools in
avian influenza (AI) control for poultry, because they increase resistance to infection, prevent …

Abstract Background Highly pathogenic H5N1 avian influenza viruses continue to spread
via waterfowl, causing lethal infections in humans. Vaccines can prevent the morbidity and …

Hypoxia and inflammation often coincide in pathogenic conditions such as acute respiratory
distress syndrome (ARDS) and chronic lung diseases, which are significant contributors to …

Considering the emergence of highly pathogenic influenza viruses and threat of worldwide
pandemics, there is an urgent need to develop broadly-protective influenza vaccines. In this …