Biocatalysis for the synthesis of active pharmaceutical ingredients in deep eutectic solvents: state-of-the-art and prospects

N Zhang, P Domínguez de María, S Kara - Catalysts, 2024 - mdpi.com
Biocatalysis holds immense potential for pharmaceutical development as it enables
synthetic routes to various chiral building blocks with unparalleled selectivity. Therein …

Sustainable setups for the biocatalytic production and scale-up of panthenyl monoacyl esters under solvent-free conditions

S Nieto, JM Bernal, R Villa… - ACS Sustainable …, 2023 - ACS Publications
A sustainable scaling-up process for the biocatalytic production of new bioactive provitamin-
B5 monoacyl esters has been demonstrated. A solvent-free reaction protocol, based on the …

[HTML][HTML] New sustainable biocatalytic approach for producing lipophilic (hydroxy) cinnamic esters based on deep eutectic mixtures

S Nieto, F Martinez-Mora, I Lozano, FJ Ruiz, R Villa… - Catalysis Today, 2024 - Elsevier
Hydroxycinnamic acids (HCAs) are naturally occurring compounds highly valued for their
bioactive properties that contribute to health benefits. The biocatalytic acylation of HCAs with …

[HTML][HTML] Influence of water content on thermophysical properties of aqueous glyceline solutions predicted by molecular dynamics simulations

MBM Spera, S Darouich, J Pleiss, N Hansen - Fluid Phase Equilibria, 2025 - Elsevier
Molecular simulations allow the prediction of a large variety of thermophysical properties for
complex mixtures based on one underlying model, ie the force field. In the present work …

[HTML][HTML] Sustainable Synthesis of New Antioxidants from Hydroxytyrosol by Direct Biocatalytic Esterification in Ionic Liquids

S Nieto, I Lozano, FJ Ruiz, JF Costa, R Villa, P Lozano - Molecules, 2024 - mdpi.com
Hydroxytyrosol (HT) is a nutraceutical compound, mainly found in the fruit, leaves and waste
from the olive oil industry, known for exhibiting one of the highest antioxidant activities …