Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models
RJ Weaver, EA Blomme, AE Chadwick… - Nature Reviews Drug …, 2020 - nature.com
Drug-induced liver injury (DILI) is a patient-specific, temporal, multifactorial
pathophysiological process that cannot yet be recapitulated in a single in vitro model …
pathophysiological process that cannot yet be recapitulated in a single in vitro model …
Human biomimetic liver microphysiology systems in drug development and precision medicine
Microphysiology systems (MPS), also called organs-on-chips and tissue chips, are
miniaturized functional units of organs constructed with multiple cell types under a variety of …
miniaturized functional units of organs constructed with multiple cell types under a variety of …
Towards in vitro models for reducing or replacing the use of animals in drug testing
Towards in vitro models for reducing or replacing the use of animals in drug testing | Nature
Biomedical Engineering Skip to main content Thank you for visiting nature.com. You are using …
Biomedical Engineering Skip to main content Thank you for visiting nature.com. You are using …
Robotic fluidic coupling and interrogation of multiple vascularized organ chips
Organ chips can recapitulate organ-level (patho) physiology, yet pharmacokinetic and
pharmacodynamic analyses require multi-organ systems linked by vascular perfusion. Here …
pharmacodynamic analyses require multi-organ systems linked by vascular perfusion. Here …
[HTML][HTML] Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development
The first microfluidic microphysiological systems (MPS) entered the academic scene more
than 15 years ago and were considered an enabling technology to human in vitro (patho) …
than 15 years ago and were considered an enabling technology to human in vitro (patho) …
Organ-on-a-chip engineering: Toward bridging the gap between lab and industry
Organ-on-a-chip (OOC) is a very ambitious emerging technology with a high potential to
revolutionize many medical and industrial sectors, particularly in preclinical-to-clinical …
revolutionize many medical and industrial sectors, particularly in preclinical-to-clinical …
Introduction to a manuscript series on the characterization and use of microphysiological systems (MPS) in pharmaceutical safety and ADME applications
K Fabre, B Berridge, WR Proctor, S Ralston, Y Will… - Lab on a Chip, 2020 - pubs.rsc.org
Safety related drug failures continue to be a challenge for pharmaceutical companies
despite the numerous complex and lengthy in vitro assays and in vivo studies that make up …
despite the numerous complex and lengthy in vitro assays and in vivo studies that make up …
Perspectives on the evaluation and adoption of complex in vitro models in drug development: Workshop with the FDA and the pharmaceutical industry (IQ MPS …
SW Baran, PC Brown, AR Baudy, SC Fitzpatrick… - ALTEX-Alternatives to …, 2022 - altex.org
Complex in vitro models (CIVM) offer the potential to improve pharmaceutical clinical drug
attrition due to safety and/or efficacy concerns. For this technology to have an impact, the …
attrition due to safety and/or efficacy concerns. For this technology to have an impact, the …
Microphysiological systems evaluation: experience of TEX-VAL tissue chip testing consortium
Much has been written and said about the promise and excitement of microphysiological
systems, miniature devices that aim to recreate aspects of human physiology on a chip. The …
systems, miniature devices that aim to recreate aspects of human physiology on a chip. The …
On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships
Functional human-on-a-chip systems hold great promise to enable quantitative translation to
in vivo outcomes. Here, we explored this concept using a pumpless heart only and heart …
in vivo outcomes. Here, we explored this concept using a pumpless heart only and heart …