Postdiagnosis body fatness, weight change and breast cancer prognosis: Global Cancer Update Program (CUP global) systematic literature review and meta‐analysis

DSM Chan, R Vieira, L Abar, D Aune… - … journal of cancer, 2023 - Wiley Online Library
Previous evidence on postdiagnosis body fatness and mortality after breast cancer was
graded as limited‐suggestive. To evaluate the evidence on body mass index (BMI), waist …

The multifactorial effect of obesity on the effectiveness and outcomes of cancer therapies

J Lysaght, MJ Conroy - Nature Reviews Endocrinology, 2024 - nature.com
Epidemiology studies have demonstrated a clear association between obesity and the
development of several distinct malignancies, with excessive visceral adiposity being an …

[HTML][HTML] Clinical impact of body mass index on palbociclib treatment outcomes and effect on exposure

R Roncato, E Peruzzi, L Gerratana, B Posocco… - Biomedicine & …, 2023 - Elsevier
The impact of body mass index (BMI) on treatment outcomes in patients with cancer is
gaining increasing attention given the limited data available. The aim of this study was to …

CDK4/6 inhibitor treatments in patients with hormone receptor positive, Her2 negative advanced breast cancer: potential molecular mechanisms, clinical implications …

M Roberto, A Astone, A Botticelli, L Carbognin… - Cancers, 2021 - mdpi.com
Simple Summary The recent addition of cyclin-dependent kinase 4 (CDK4) and CDK6
inhibitors (palbociclib, ribociclib, abemaciclib) to endocrine therapy have remarkably …

Impact of BMI in patients with early hormone receptor–positive breast cancer receiving endocrine therapy with or without palbociclib in the PALLAS trial

G Pfeiler, D Hlauschek, EL Mayer… - Journal of Clinical …, 2023 - ascopubs.org
PURPOSE BMI affects breast cancer risk and prognosis. In contrast to cytotoxic
chemotherapy, CDK4/6 inhibitors are given at a fixed dose, irrespective of BMI or weight …

The challenges of treating patients with breast cancer and obesity

A LeVee, J Mortimer - Cancers, 2023 - mdpi.com
Simple Summary Obesity is a poor prognostic factor for patients with breast cancer, resulting
in increased risk of recurrence and death due to breast cancer. Obesity can affect both the …

Reporting on patient's body mass index (BMI) in recent clinical trials for patients with breast cancer: a systematic review

J Van Cauwenberge, K Van Baelen, M Maetens… - Breast Cancer …, 2024 - Springer
Background The proportion of patients with breast cancer and obesity is increasing. While
the therapeutic landscape of breast cancer has been expanding, we lack knowledge about …

Living with metastatic cancer: a roadmap for future research

DB Tometich, KA Hyland, H Soliman, HSL Jim… - Cancers, 2020 - mdpi.com
Simple Summary Although people with metastatic cancer are living longer with their
disease, they are faced with challenges that can interfere with their quality of life. These …

The obesity paradox in early and advanced HER2 positive breast cancer: pooled analysis of clinical trial data

ND Modi, JQE Tan, A Rowland, B Koczwara… - NPJ Breast …, 2021 - nature.com
While many studies have evaluated the relationship between BMI and breast cancer
outcomes, it is unclear whether this relationship is consistent between early breast cancer …

[HTML][HTML] Impact of body mass index on overall survival in patients with metastatic breast cancer

K Saleh, M Carton, V Dieras, PE Heudel, E Brain… - The Breast, 2021 - Elsevier
Abstract Background High Body mass index (BMI) is a risk factor for breast cancer among
postmenopausal women and an adverse prognostic factor in early-stage. Little is known …