Platinum group metal (PGM) complexes having acylthiourea ligand system as catalysts or anticancer agents

S Swaminathan, P Jerome, RJ Deepak… - Coordination Chemistry …, 2024 - Elsevier
The intention behind the design of a metal complex is quite crucial for its development
towards a particular application. Transition metal complexes have tremendously become …

An overview on the anticancer activity of Ru (II)/acylthiourea complexes

GH Ribeiro, AR Costa, AR de Souza… - Coordination Chemistry …, 2023 - Elsevier
This review outlines research on the development of ruthenium complexes containing
acylthiourea ligands with potential antitumor activity, which have been leveraged in recent …

Piano stool Ru (II)-arene complexes having three monodentate legs: A comprehensive review on their development as anticancer therapeutics over the past decade

S Swaminathan, J Haribabu, N Balakrishnan… - Coordination chemistry …, 2022 - Elsevier
The popularity of RAPTA-C in in vivo studies has steered the way for complexes of the type
[Ru (η 6-arene)(X)(Y)(Z)] n+ (where X, Y and Z are monodentate ligands) to be developed …

Impact of aliphatic acyl and aromatic thioamide substituents on the anticancer activity of Ru (ii)-p-cymene complexes with acylthiourea ligands—in vitro and in vivo …

S Swaminathan, J Haribabu, MKM Subarkhan… - Dalton …, 2021 - pubs.rsc.org
Six different acylthiourea ligands (L1–L6) and their corresponding Ru (II)-p-cymene
complexes (P1–P6) were designed to explore the structure–activity relationship of the …

Monodentately-coordinated bioactive moieties in multimodal half-sandwich organoruthenium anticancer agents

TR Steel, F Walsh, A Wieczorek-Błauż, M Hanif… - Coordination chemistry …, 2021 - Elsevier
Metallodrugs have a central role in the treatment and diagnosis of diseases. To overcome
potential toxicity and equip metal-based anticancer agents with biological activity, the choice …

[HTML][HTML] Anticancer half-sandwich rhodium (III) complexes

K Máliková, L Masaryk, P Štarha - Inorganics, 2021 - mdpi.com
Platinum-based anticancer drugs are most likely the most successful group of bioinorganic
compounds. Their apparent disadvantages have led to the development of anticancer …

Effect of N,N Coordination and RuII Halide Bond in Enhancing Selective Toxicity of a Tyramine-Based RuII (p-Cymene) Complex

A Mukherjee, S Acharya, K Purkait… - Inorganic …, 2020 - ACS Publications
Ruthenium compounds are promising anticancer candidates owing to their lower side-
effects and encouraging activities against resistant tumors. Half-sandwich piano-stool type …

Synthesis of new thiourea-metal complexes with promising anticancer properties

G Canudo-Barreras, L Ortego, A Izaga, I Marzo… - Molecules, 2021 - mdpi.com
In this work, two thiourea ligands bearing a phosphine group in one arm and in the other a
phenyl group (T2) or 3, 5-di-CF3 substituted phenyl ring (T1) have been prepared and their …

[HTML][HTML] Antitumor neodymium (III) complex with 1, 10-phenanthroline and nitrate ligands: A comprehensive experimental-theoretical study, in silico pharmacokinetic …

JG de Oliveira Neto, JR Viana, KR Abreu… - Journal of Molecular …, 2025 - Elsevier
Here we report the crystallization of the tris (nitrate-O, O')-bis (1, 10-phenanthroline-N, N')-
neodymium (III) complex by the slow solvent evaporation method. Structural, electronic …

[HTML][HTML] Dichloro-bis (theophylline)-copper (II) complex: Characterization of the physicochemical, computational pharmacokinetics, molecular docking, and cytotoxicity …

JG de Oliveira Neto, JR Viana, MVS Júnior… - Polyhedron, 2024 - Elsevier
Abstract A dichloro-bis (theophylline)-copper (II) complex, named [Cu (theo) 2 Cl 2], was
synthesized, with the aim to characterize its physicochemical and pharmacological …