Symbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colon

A Nakamura, S Kurihara, D Takahashi… - Nature …, 2021 - nature.com
Intestinal microbiota-derived metabolites have biological importance for the host.
Polyamines, such as putrescine and spermidine, are produced by the intestinal microbiota …

Birth mode is associated with earliest strain-conferred gut microbiome functions and immunostimulatory potential

L Wampach, A Heintz-Buschart, JV Fritz… - Nature …, 2018 - nature.com
The rate of caesarean section delivery (CSD) is increasing worldwide. It remains unclear
whether disruption of mother-to-neonate transmission of microbiota through CSD occurs and …

Biofilm exopolysaccharides alter sensory-neuron-mediated sickness during lung infection

E Granton, L Brown, M Defaye, P Moazen, H Almblad… - Cell, 2024 - cell.com
Infections of the lung cause observable sickness thought to be secondary to inflammation.
Signs of sickness are crucial to alert others via behavioral-immune responses to limit contact …

Prevalence and Some Possible Mechanisms of Colistin Resistance Among Multidrug-Resistant and Extensively Drug-Resistant Pseudomonas aeruginosa

RM Abd El-Baky, SM Masoud… - Infection and Drug …, 2020 - Taylor & Francis
Background and Aim The emergence of colistin-resistant strains is considered a great threat
for patients with severe infections. Here, we investigate the prevalence and some possible …

Opposite evolution of pathogenicity driven by in vivo wzc and wcaJ mutations in ST11-KL64 carbapenem-resistant Klebsiella pneumoniae

J He, Q Shi, Z Chen, W Zhang, P Lan, Q Xu, H Hu… - Drug Resistance …, 2023 - Elsevier
Aims To investigate the in vivo evolution of the mucoid-phenotype of ST11-KL64
carbapenem-resistant Klebsiella pneumoniae (CRKP) isolated from the same patients and …

The serogroup B meningococcal outer membrane vesicle-based vaccine 4CMenB induces cross-species protection against Neisseria gonorrhoeae

I Leduc, KL Connolly, A Begum, K Underwood… - PLoS …, 2020 - journals.plos.org
There is a pressing need for a gonorrhea vaccine due to the high disease burden
associated with gonococcal infections globally and the rapid evolution of antibiotic …

Colistin-phage combinations decrease antibiotic resistance in Acinetobacter baumannii via changes in envelope architecture

X Wang, B Loh, F Gordillo Altamirano, Y Yu… - Emerging microbes & …, 2021 - Taylor & Francis
Multidrug-resistant bacterial infections are becoming increasingly common, with only few
last-resort antibiotics such as colistin available for clinical therapy. An alternative therapeutic …

Evaluation of the impact of repeated intravenous phage doses on mammalian host–phage interactions

X Tan, K Chen, Z Jiang, Z Liu, S Wang, Y Ying… - Journal of …, 2024 - journals.asm.org
Phage therapy has shown great promise for the treatment of multidrug-resistant bacterial
infections. However, the lack of a thorough and organized understanding of phage–body …

Rapid expansion and extinction of antibiotic resistance mutations during treatment of acute bacterial respiratory infections

H Chung, C Merakou, MM Schaefers, KB Flett… - Nature …, 2022 - nature.com
Acute bacterial infections are often treated empirically, with the choice of antibiotic therapy
updated during treatment. The effects of such rapid antibiotic switching on the evolution of …

A proteolytically activated antimicrobial toxin encoded on a mobile plasmid of Bacteroidales induces a protective response

JC Evans, VL McEneany, MJ Coyne… - Nature …, 2022 - nature.com
Phocaeicola vulgatus is one of the most abundant and ubiquitous bacterial species of the
human gut microbiota, yet a comprehensive analysis of antibacterial toxin production by …