A comprehensive review on medicinal plants as antimicrobial therapeutics: potential avenues of biocompatible drug discovery
U Anand, N Jacobo-Herrera, A Altemimi, N Lakhssassi - Metabolites, 2019 - mdpi.com
The war on multidrug resistance (MDR) has resulted in the greatest loss to the world's
economy. Antibiotics, the bedrock, and wonder drug of the 20th century have played a …
economy. Antibiotics, the bedrock, and wonder drug of the 20th century have played a …
Software tools and approaches for compound identification of LC-MS/MS data in metabolomics
The annotation of small molecules remains a major challenge in untargeted mass
spectrometry-based metabolomics. We here critically discuss structured elucidation …
spectrometry-based metabolomics. We here critically discuss structured elucidation …
A computational framework to explore large-scale biosynthetic diversity
JC Navarro-Muñoz, N Selem-Mojica… - Nature chemical …, 2020 - nature.com
Genome mining has become a key technology to exploit natural product diversity. Although
initially performed on a single-genome basis, the process is now being scaled up to mine …
initially performed on a single-genome basis, the process is now being scaled up to mine …
[HTML][HTML] Biosynthetic potential of the global ocean microbiome
Natural microbial communities are phylogenetically and metabolically diverse. In addition to
underexplored organismal groups, this diversity encompasses a rich discovery potential for …
underexplored organismal groups, this diversity encompasses a rich discovery potential for …
Chemical evolution of natural product structure
M Grigalunas, S Brakmann… - Journal of the American …, 2022 - ACS Publications
Natural products are the result of Nature's exploration of biologically relevant chemical
space through evolution and an invaluable source of bioactive small molecules for chemical …
space through evolution and an invaluable source of bioactive small molecules for chemical …
Marine natural products
Covering: January to December 2017 This review covers the literature published in 2017 for
marine natural products (MNPs), with 740 citations (723 for the period January to December …
marine natural products (MNPs), with 740 citations (723 for the period January to December …
Mining genomes to illuminate the specialized chemistry of life
All organisms produce specialized organic molecules, ranging from small volatile chemicals
to large gene-encoded peptides, that have evolved to provide them with diverse cellular and …
to large gene-encoded peptides, that have evolved to provide them with diverse cellular and …
IMPPAT: A curated database of I ndian M edicinal P lants, P hytochemistry A nd T herapeutics
Phytochemicals of medicinal plants encompass a diverse chemical space for drug
discovery. India is rich with a flora of indigenous medicinal plants that have been used for …
discovery. India is rich with a flora of indigenous medicinal plants that have been used for …
NPClassifier: a deep neural network-based structural classification tool for natural products
Computational approaches such as genome and metabolome mining are becoming
essential to natural products (NPs) research. Consequently, a need exists for an automated …
essential to natural products (NPs) research. Consequently, a need exists for an automated …
Strategies to access biosynthetic novelty in bacterial genomes for drug discovery
F Hemmerling, J Piel - Nature Reviews Drug Discovery, 2022 - nature.com
Bacteria provide a rich source of natural products with potential therapeutic applications,
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …