Graft-versus-host disease (GVHD) remains a major cause of morbidity and mortality after
allogeneic stem cell transplantation (SCT). Currently, more patients can receive SCT. This is …

Autoimmune hepatitis (AIH) is an orphan disease characterized by an autoimmune attack
against hepatocytes. The exact sequence of events that leads to a breach of tolerance is …

Bone marrow transplantation (BMT) to treat severe hematologic malignancies often leads to
potentially fatal acute graft-versus-host disease (GVHD), despite attempts at better donor …

Background Endogenous PIF, upon which embryo development is dependent, is secreted
only by viable mammalian embryos, and absent in non-viable ones. Synthetic PIF (sPIF) …

Embryonic–maternal interaction from the earliest stages of gestation has a key, sustained
role in neurologic development, persisting into adulthood. Early adverse events may be …

PreImplantation factor (PIF) is a 15-amino acid peptide endogenously secreted by viable
embryos, regulating/enabling maternal (host) acceptance/tolerance to the “invading” embryo …

Background/Aims: Pregnancy success requires mandatory maternal tolerance of the
semi/allogeneic embryo involving embryo-derived signals. Expression levels of …

From the earliest stages of gestation, embryonic–maternal interaction has a key role in a
successful pregnancy. Various factors present during gestation may significantly influence …

Abstract PreImplantation Factor (PIF 9&15) secreted by viable embryos exerts an essential
transplant acceptance and immune regulatory role in pregnancy. Synthetic PIF replicates …

Preimplantation factor (PIF) is an evolutionary conserved peptide secreted by viable
embryos which promotes maternal tolerance without immune suppression. Synthetic PIF …