Protein-protein interactions are important for nearly all biological processes, and it is known
that aberrant protein-protein interactions can lead to human disease and cancer. Recent …

Analysis of protein interaction networks and protein complexes using affinity purification and
mass spectrometry (AP/MS) is among most commonly used and successful applications of …

Quantitative shotgun proteomics is dependent on the detection, identification, and
quantitative analysis of peptides. An issue arises with peptides that are shared between …

Despite the availability of several large‐scale proteomics studies aiming to identify protein
interactions on a global scale, little is known about how proteins interact and are organized …

The Rpd3L histone deacetylase (HDAC) complex is an ancient 12-subunit complex
conserved in a broad range of eukaryotes that performs localized deacetylation at or near …

The use of quantitative proteomics methods to study protein complexes has the potential to
provide in-depth information on the abundance of different protein components as well as …

Transcriptional memory is critical for the faster reactivation of necessary genes upon
environmental changes and requires that the genes were previously in an active state …

The steady‐state level of histone acetylation is maintained by histone acetyltransferase
(HAT) and histone deacetylase (HDAC) complexes. INhibitor of Growth (ING) proteins are …

The identification of interactions between viral and host cellular proteins has provided major
insights into papillomavirus research, and these interactions are especially relevant to the …

Lysine acetylation is a dynamic posttranslational modification with a well-defined role in
regulating histones. The impact of acetylation on other cellular functions remains relatively …