Specific gene expression involves the binding of natural ligands to the DNA base pairs.
Among the compounds rationally designed for artificial regulation of gene expression …

Triplex-forming oligonucleotides (TFOs) can bind to polypurine/polypyrimidine regions in
DNA in a sequence-specific manner. The specificity of this binding raises the possibility of …

Conjugates of therapeutic oligonucleotides (ONs) including peptide conjugates, provide a
potential solution to the major challenge of specific tissue delivery faced by this class of …

The novel bridged nucleic-acid analogue 2 ', 4 '-BNANC (2 '-O, 4 '-C-aminomethylene
bridged nucleic acid), containing a six-membered bridged structure with an N− O linkage …

The potential of chemically modified oligonucleotide (ON) analogues as therapeutic agents
or diagnostic molecules has stimulated great interest in nucleic acid mimics during recent …

DNA triple-helix-based approaches to control and modulate cellular functions on the level of
genomic DNA (antigene technology) suffered in the past from a stepmother-like treatment in …

We have used oligonucleotides containing molecular beacons to determine melting profiles
for intramolecular DNA duplexes, triplexes and quadruplexes (tetraplexes). The synthetic …

We have achieved recognition of all 4 bp by triple helix formation at physiological pH, using
triplex-forming oligonucleotides that contain four different synthetic nucleotides. BAU [2 …

A procedure is presented for copper (I)-catalyzed [3+ 2] cycloaddition of nucleosides and
nucleotides in near-quantitative yield. Azido− alkyne cycloaddition was applied for the …

The preservation of nucleus structure during microscopy imaging is a top priority for
understanding chromatin organization, genome dynamics, and gene expression regulation …